PTEN overexpression and nuclear β-catenin stabilization promote morular differentiation through induction of epithelial–mesenchymal transition and cancer stem cell-like properties in endometrial carcinoma

PTEN overexpression and nuclear β-catenin stabilization promote morular differentiation through induction of epithelial–mesenchymal transition and cancer stem cell-like properties in endometrial carcinoma

Abstract Background Although a lack of functional PTEN contributes to tumorigenesis in a wide spectrum of human malignancies, little is known about the functional role of its overexpression in the tumors. The current study focused on PTEN overexpression in endometrial carcinoma (Em Ca). Methods The...

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Bibliographic Details
Main Authors: Ako Yokoi, Marina Minami, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Yoshinori Hasegawa, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa, Makoto Saegusa
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cell Communication and Signaling
Subjects:
PTEN
β-catenin
EBP50
Cancer stem cell
Endometrial carcinoma
Morule
Online Access:https://doi.org/10.1186/s12964-022-00999-w

Internet

https://doi.org/10.1186/s12964-022-00999-w

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