The non-canonical role of Aurora-A in DNA replication
Aurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role. During mitosis, Aurora-A protein is stabilized by its phosphorylation at Ser51 via blocking anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis. Impor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00187/full |
| _version_ | 1818906288630792192 |
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| author | Takaaki eTsunematsu Rieko eArakaki Akiko eYamada Naozumi eIshimaru Yasusei eKudo |
| author_facet | Takaaki eTsunematsu Rieko eArakaki Akiko eYamada Naozumi eIshimaru Yasusei eKudo |
| author_sort | Takaaki eTsunematsu |
| collection | DOAJ |
| description | Aurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role. During mitosis, Aurora-A protein is stabilized by its phosphorylation at Ser51 via blocking anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis. Importantly, overexpression and/or hyperactivation of Aurora-A is involved in tumorigenesis via aneuploidy and genomic instability. Recently, the novel function of Aurora-A for DNA replication has been revealed. In mammalian cells, DNA replication is strictly regulated for preventing over-replication. Pre-replication complex (pre-RC) formation is required for DNA replication as an initiation step occurring at the origin of replication. The timing of pre-RC formation depends on the protein level of geminin, which is controlled by the ubiquitin–proteasome pathway. Aurora-A phosphorylates geminin to prevent its ubiquitin-mediated proteolysis at the mitotic phase to ensure proper pre-RC formation and ensuing DNA replication. In this review, we introduce the novel non-canonical role of Aurora-A in DNA replication. |
| first_indexed | 2024-12-19T21:36:51Z |
| format | Article |
| id | doaj.art-5c33c63a127e449098e43b8392c7d769 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T21:36:51Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5c33c63a127e449098e43b8392c7d7692022-12-21T20:04:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-08-01510.3389/fonc.2015.00187153403The non-canonical role of Aurora-A in DNA replicationTakaaki eTsunematsu0Rieko eArakaki1Akiko eYamada2Naozumi eIshimaru3Yasusei eKudo4Tokushima University Graduate SchoolTokushima University Graduate SchoolTokushima University Graduate SchoolTokushima University Graduate SchoolTokushima University Graduate SchoolAurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role. During mitosis, Aurora-A protein is stabilized by its phosphorylation at Ser51 via blocking anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis. Importantly, overexpression and/or hyperactivation of Aurora-A is involved in tumorigenesis via aneuploidy and genomic instability. Recently, the novel function of Aurora-A for DNA replication has been revealed. In mammalian cells, DNA replication is strictly regulated for preventing over-replication. Pre-replication complex (pre-RC) formation is required for DNA replication as an initiation step occurring at the origin of replication. The timing of pre-RC formation depends on the protein level of geminin, which is controlled by the ubiquitin–proteasome pathway. Aurora-A phosphorylates geminin to prevent its ubiquitin-mediated proteolysis at the mitotic phase to ensure proper pre-RC formation and ensuing DNA replication. In this review, we introduce the novel non-canonical role of Aurora-A in DNA replication.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00187/fullDNA ReplicationUbiquitindegradationProteasomeAurora-Ageminin |
| spellingShingle | Takaaki eTsunematsu Rieko eArakaki Akiko eYamada Naozumi eIshimaru Yasusei eKudo The non-canonical role of Aurora-A in DNA replication Frontiers in Oncology DNA Replication Ubiquitin degradation Proteasome Aurora-A geminin |
| title | The non-canonical role of Aurora-A in DNA replication |
| title_full | The non-canonical role of Aurora-A in DNA replication |
| title_fullStr | The non-canonical role of Aurora-A in DNA replication |
| title_full_unstemmed | The non-canonical role of Aurora-A in DNA replication |
| title_short | The non-canonical role of Aurora-A in DNA replication |
| title_sort | non canonical role of aurora a in dna replication |
| topic | DNA Replication Ubiquitin degradation Proteasome Aurora-A geminin |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00187/full |
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