Characterization of the 3'UTR of the BTD gene and identification of regulatory elements and microRNAs

Characterization of the 3'UTR of the BTD gene and identification of regulatory elements and microRNAs

Abstract Reduced biotinidase activity is associated with a spectrum of deficiency ranging from total deficiency to heterozygous levels, a finding that is not always explained by the pathogenic variants observed in the BTD gene. The investigation of miRNAs, regulatory elements and variants in the 3’U...

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Bibliographic Details
Main Authors: Gerda Cristal Villalba Silva, Taciane Borsatto, Ida Vanessa Doederlein Schwartz, Fernanda Sperb-Ludwig
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2022-02-01
Series:Genetics and Molecular Biology
Subjects:
3′UTR
genetic variants
miRNAs
AU-rich elements
biotinidase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000100105&lng=en&tlng=en

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