Reductive amination with zinc powder in aqueous media
Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2011-08-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.7.125 |
| _version_ | 1818428185284444160 |
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| author | Giovanni B. Giovenzana Daniela Imperio Andrea Penoni Giovanni Palmisano |
| author_facet | Giovanni B. Giovenzana Daniela Imperio Andrea Penoni Giovanni Palmisano |
| author_sort | Giovanni B. Giovenzana |
| collection | DOAJ |
| description | Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents. |
| first_indexed | 2024-12-14T14:57:36Z |
| format | Article |
| id | doaj.art-5c36febb2d854c02b88fe202a7772086 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T14:57:36Z |
| publishDate | 2011-08-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-5c36febb2d854c02b88fe202a77720862022-12-21T22:56:58ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972011-08-01711095109910.3762/bjoc.7.1251860-5397-7-125Reductive amination with zinc powder in aqueous mediaGiovanni B. Giovenzana0Daniela Imperio1Andrea Penoni2Giovanni Palmisano3DiSCAFF, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, I-28100 Novara, Italy; Fax: +39-(0)321-375821, Tel: +39-(0)321-375846DiSCAFF, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, I-28100 Novara, Italy; Fax: +39-(0)321-375821, Tel: +39-(0)321-375846Dipartimento di Scienze Chimiche e Ambientali, Università dell’Insubria, Via Valleggio 11, I-22100 Como, Italy; Fax: +39-(0)31-2386449, Tel: +39-(0)31-2386234Dipartimento di Scienze Chimiche e Ambientali, Università dell’Insubria, Via Valleggio 11, I-22100 Como, Italy; Fax: +39-(0)31-2386449, Tel: +39-(0)31-2386234Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.https://doi.org/10.3762/bjoc.7.125aldehydesaminesreductive aminationwaterzinc |
| spellingShingle | Giovanni B. Giovenzana Daniela Imperio Andrea Penoni Giovanni Palmisano Reductive amination with zinc powder in aqueous media Beilstein Journal of Organic Chemistry aldehydes amines reductive amination water zinc |
| title | Reductive amination with zinc powder in aqueous media |
| title_full | Reductive amination with zinc powder in aqueous media |
| title_fullStr | Reductive amination with zinc powder in aqueous media |
| title_full_unstemmed | Reductive amination with zinc powder in aqueous media |
| title_short | Reductive amination with zinc powder in aqueous media |
| title_sort | reductive amination with zinc powder in aqueous media |
| topic | aldehydes amines reductive amination water zinc |
| url | https://doi.org/10.3762/bjoc.7.125 |
| work_keys_str_mv | AT giovannibgiovenzana reductiveaminationwithzincpowderinaqueousmedia AT danielaimperio reductiveaminationwithzincpowderinaqueousmedia AT andreapenoni reductiveaminationwithzincpowderinaqueousmedia AT giovannipalmisano reductiveaminationwithzincpowderinaqueousmedia |