Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytone...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/6/300 |
| _version_ | 1797566086854475776 |
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| author | Moo Rim Kang Sun Ah Jo Hyunju Lee Yeo Dae Yoon Joo-Hee Kwon Jeong-Wook Yang Byeong Jo Choi Ki Hwan Park Myeong Youl Lee Chang Woo Lee Kyeong-Ryoon Lee Jong Soon Kang |
| author_facet | Moo Rim Kang Sun Ah Jo Hyunju Lee Yeo Dae Yoon Joo-Hee Kwon Jeong-Wook Yang Byeong Jo Choi Ki Hwan Park Myeong Youl Lee Chang Woo Lee Kyeong-Ryoon Lee Jong Soon Kang |
| author_sort | Moo Rim Kang |
| collection | DOAJ |
| description | Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-<i>O</i>-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-α and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-α and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-κB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IκBα and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-κB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation. |
| first_indexed | 2024-03-10T19:21:45Z |
| format | Article |
| id | doaj.art-5c388d99f3e247e6a1abe0dce7d0354e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T19:21:45Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-5c388d99f3e247e6a1abe0dce7d0354e2023-11-20T02:52:24ZengMDPI AGMarine Drugs1660-33972020-06-0118630010.3390/md18060300Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen PigmentMoo Rim Kang0Sun Ah Jo1Hyunju Lee2Yeo Dae Yoon3Joo-Hee Kwon4Jeong-Wook Yang5Byeong Jo Choi6Ki Hwan Park7Myeong Youl Lee8Chang Woo Lee9Kyeong-Ryoon Lee10Jong Soon Kang11Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaScytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-<i>O</i>-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-α and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-α and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-κB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IκBα and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-κB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation.https://www.mdpi.com/1660-3397/18/6/300scytoneminskin inflammationtumor necrosis factor-αnitric oxideNF-κB |
| spellingShingle | Moo Rim Kang Sun Ah Jo Hyunju Lee Yeo Dae Yoon Joo-Hee Kwon Jeong-Wook Yang Byeong Jo Choi Ki Hwan Park Myeong Youl Lee Chang Woo Lee Kyeong-Ryoon Lee Jong Soon Kang Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment Marine Drugs scytonemin skin inflammation tumor necrosis factor-α nitric oxide NF-κB |
| title | Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment |
| title_full | Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment |
| title_fullStr | Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment |
| title_full_unstemmed | Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment |
| title_short | Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment |
| title_sort | inhibition of skin inflammation by scytonemin an ultraviolet sunscreen pigment |
| topic | scytonemin skin inflammation tumor necrosis factor-α nitric oxide NF-κB |
| url | https://www.mdpi.com/1660-3397/18/6/300 |
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