In Vivo Pravastatin Treatment Reverses Hypercholesterolemia Induced Mitochondria-Associated Membranes Contact Sites, Foam Cell Formation, and Phagocytosis in Macrophages

In Vivo Pravastatin Treatment Reverses Hypercholesterolemia Induced Mitochondria-Associated Membranes Contact Sites, Foam Cell Formation, and Phagocytosis in Macrophages

Statins are successful drugs used to treat hypercholesterolemia, a primary cause of atherosclerosis. In this work, we investigated how hypercholesterolemia and pravastatin treatment impact macrophage and mitochondria functions, the key cell involved in atherogenesis. By comparing bone marrow-derived...

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Bibliographic Details
Main Authors: Leandro Henrique de Paula Assis, Gabriel de Gabriel Dorighello, Thiago Rentz, Jane Cristina de Souza, Aníbal Eugênio Vercesi, Helena Coutinho Franco de Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
hypercholesterolemia
statin
macrophage
mitochondria-associated membrane
foam cell
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.839428/full

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