PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
ADPKD, a common aetiology of kidney failure, is caused by heterozygous PKD1 or PKD2 mutations. Here the authors show that preventing 3′-UTR cis-inhibition of mRNAs produced by the non-inactivated PKD1/2 alleles ameliorates preclinical ADPKD.
Bibliographic Details
| Main Authors: |
Ronak Lakhia,
Harini Ramalingam,
Chun-Mien Chang,
Patricia Cobo-Stark,
Laurence Biggers,
Andrea Flaten,
Jesus Alvarez,
Tania Valencia,
Darren P. Wallace,
Edmund C. Lee,
Vishal Patel |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32543-2
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