Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind
Monkeypox Virus (MPV) causes rare zoonotic illness. The Central African (or Congo Basin) clade and the West African clade are its two genetic subgroups, of which Central African subgroup is more lethal. To distinguish between the lineages, sequencing is crucial. As it was first isolated from captive...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/17721/61291_CE[Ra1]_F(IS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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| author | Ashwini Arun Mankar Suvarna Vaibhav Sande Priyanka Purushottam Chaubey |
| author_facet | Ashwini Arun Mankar Suvarna Vaibhav Sande Priyanka Purushottam Chaubey |
| author_sort | Ashwini Arun Mankar |
| collection | DOAJ |
| description | Monkeypox Virus (MPV) causes rare zoonotic illness. The Central African (or Congo Basin) clade and the West African clade are its two genetic subgroups, of which Central African subgroup is more lethal. To distinguish between the lineages, sequencing is crucial. As it was first isolated from captive monkeys that is why it is named as MPV. Its clinical features are similar to small pox. Undiagnosed acute rash with one or more symptoms, such as headache, fever, lymphadenopathy, myalgia, back pain, or asthenia, are considered common clinical findings. Real-Time Polymerase Chain Reaction (RT-PCR) is used in the laboratory diagnosis. There are various complications of monkeypox disease that includes bacterial infection of skin, skin scarring, hyper or hypopigmentation, permanent corneal scarring (vision loss), pneumonia, dehydration, sepsis, encephalitis and death. The drug of choice includes Tecovirimat, Cidofovir, Vaccinia Immune Globulin Intravenous (VIGIV), Brincidofovir. ACAM2000, LC16m8 and modified vaccinia Ankara are few options for vaccines but still under investigation. Though the disease is self-limiting but may complicate and has morbidity as well as mortality. So, it’s better to prevent the spread of the disease by early identification, contact tracing, isolation with stringent hospital infection control practices with early initiation of treatment. |
| first_indexed | 2024-04-09T17:57:54Z |
| format | Article |
| id | doaj.art-5c3e5db6f5564033a37d4292dffc2740 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-09T17:57:54Z |
| publishDate | 2023-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5c3e5db6f5564033a37d4292dffc27402023-04-14T10:38:19ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-04-01174DE06DE1010.7860/JCDR/2023/61291.17721Monkeypox: An Uncommon Re-emerging Virus- Threat to MankindAshwini Arun Mankar0Suvarna Vaibhav Sande1Priyanka Purushottam Chaubey2Assistant Professor, Department of Microbiology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, Maharashtra, India.Professor, Department of Microbiology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, Maharashtra, India.Assistant Professor, Department of Microbiology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, Maharashtra, India.Monkeypox Virus (MPV) causes rare zoonotic illness. The Central African (or Congo Basin) clade and the West African clade are its two genetic subgroups, of which Central African subgroup is more lethal. To distinguish between the lineages, sequencing is crucial. As it was first isolated from captive monkeys that is why it is named as MPV. Its clinical features are similar to small pox. Undiagnosed acute rash with one or more symptoms, such as headache, fever, lymphadenopathy, myalgia, back pain, or asthenia, are considered common clinical findings. Real-Time Polymerase Chain Reaction (RT-PCR) is used in the laboratory diagnosis. There are various complications of monkeypox disease that includes bacterial infection of skin, skin scarring, hyper or hypopigmentation, permanent corneal scarring (vision loss), pneumonia, dehydration, sepsis, encephalitis and death. The drug of choice includes Tecovirimat, Cidofovir, Vaccinia Immune Globulin Intravenous (VIGIV), Brincidofovir. ACAM2000, LC16m8 and modified vaccinia Ankara are few options for vaccines but still under investigation. Though the disease is self-limiting but may complicate and has morbidity as well as mortality. So, it’s better to prevent the spread of the disease by early identification, contact tracing, isolation with stringent hospital infection control practices with early initiation of treatment.https://www.jcdr.net/articles/PDF/17721/61291_CE[Ra1]_F(IS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdfcentral african cladecytopathic effectmonkeypox viruswest african clade |
| spellingShingle | Ashwini Arun Mankar Suvarna Vaibhav Sande Priyanka Purushottam Chaubey Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind Journal of Clinical and Diagnostic Research central african clade cytopathic effect monkeypox virus west african clade |
| title | Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind |
| title_full | Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind |
| title_fullStr | Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind |
| title_full_unstemmed | Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind |
| title_short | Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind |
| title_sort | monkeypox an uncommon re emerging virus threat to mankind |
| topic | central african clade cytopathic effect monkeypox virus west african clade |
| url | https://www.jcdr.net/articles/PDF/17721/61291_CE[Ra1]_F(IS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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