Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study
Abstract Background Previous studies have shown inconsistent findings regarding the association of light to moderate alcohol consumption with cause-specific mortality. Therefore, this study sought to examine the prospective association of alcohol consumption with all-cause and cause-specific mortali...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
|
| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-023-02907-6 |
| _version_ | 1797784557204799488 |
|---|---|
| author | Yalan Tian Jiahui Liu Yue Zhao Nana Jiang Xiao Liu Gang Zhao Xia Wang |
| author_facet | Yalan Tian Jiahui Liu Yue Zhao Nana Jiang Xiao Liu Gang Zhao Xia Wang |
| author_sort | Yalan Tian |
| collection | DOAJ |
| description | Abstract Background Previous studies have shown inconsistent findings regarding the association of light to moderate alcohol consumption with cause-specific mortality. Therefore, this study sought to examine the prospective association of alcohol consumption with all-cause and cause-specific mortality in the US population. Methods This was a population-based cohort study of adults aged 18 years or older in the National Health Interview Survey (1997 to 2014) with linkage to the National Death Index records through December 31, 2019. Self-reported alcohol consumption was categorized into seven groups (lifetime abstainers; former infrequent or regular drinkers; and current infrequent, light, moderate, or heavy drinkers). The main outcome was all-cause and cause-specific mortality. Results During an average follow-up of 12.65 years, among the 918,529 participants (mean age 46.1 years; 48.0% male), 141,512 adults died from all causes, 43,979 from cardiovascular disease (CVD), 33,222 from cancer, 8246 from chronic lower respiratory tract diseases, 5572 from accidents (unintentional injuries), 4776 from Alzheimer’s disease, 4845 from diabetes mellitus, 2815 from influenza and pneumonia, and 2692 from nephritis, nephrotic syndrome, or nephrosis. Compared with lifetime abstainers, current infrequent, light, or moderate drinkers were at a lower risk of mortality from all causes [infrequent—hazard ratio: 0.87; 95% confidence interval: 0.84 to 0.90; light: 0.77; 0.75 to 0.79; moderate 0.82; 0.80 to 0.85], CVD, chronic lower respiratory tract diseases, Alzheimer’s disease, and influenza and pneumonia. Also, light or moderate drinkers were associated with lower risk of mortality from diabetes mellitus and nephritis, nephrotic syndrome, or nephrosis. In contrast, heavy drinkers had a significantly higher risk of mortality from all causes, cancer, and accidents (unintentional injuries). Furthermore, binge drinking ≥ 1 day/week was associated with a higher risk of mortality from all causes (1.15; 1.09 to 1.22), cancer (1.22; 1.10 to 1.35), and accidents (unintentional injuries) (1.39; 1.11 to 1.74). Conclusions Infrequent, light, and moderate alcohol consumption were inversely associated with mortality from all causes, CVD, chronic lower respiratory tract diseases, Alzheimer’s disease, and influenza and pneumonia. Light or moderate alcohol consumption might also have a beneficial effect on mortality from diabetes mellitus and nephritis, nephrotic syndrome, or nephrosis. However, heavy or binge had a higher risk of all-cause, cancer, and accidents (unintentional injuries) mortality. |
| first_indexed | 2024-03-13T00:41:35Z |
| format | Article |
| id | doaj.art-5c40ae8cb63a4e35b9da7ed40807e95e |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-03-13T00:41:35Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-5c40ae8cb63a4e35b9da7ed40807e95e2023-07-09T11:15:56ZengBMCBMC Medicine1741-70152023-06-0121111510.1186/s12916-023-02907-6Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort studyYalan Tian0Jiahui Liu1Yue Zhao2Nana Jiang3Xiao Liu4Gang Zhao5Xia Wang6Department of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityAbstract Background Previous studies have shown inconsistent findings regarding the association of light to moderate alcohol consumption with cause-specific mortality. Therefore, this study sought to examine the prospective association of alcohol consumption with all-cause and cause-specific mortality in the US population. Methods This was a population-based cohort study of adults aged 18 years or older in the National Health Interview Survey (1997 to 2014) with linkage to the National Death Index records through December 31, 2019. Self-reported alcohol consumption was categorized into seven groups (lifetime abstainers; former infrequent or regular drinkers; and current infrequent, light, moderate, or heavy drinkers). The main outcome was all-cause and cause-specific mortality. Results During an average follow-up of 12.65 years, among the 918,529 participants (mean age 46.1 years; 48.0% male), 141,512 adults died from all causes, 43,979 from cardiovascular disease (CVD), 33,222 from cancer, 8246 from chronic lower respiratory tract diseases, 5572 from accidents (unintentional injuries), 4776 from Alzheimer’s disease, 4845 from diabetes mellitus, 2815 from influenza and pneumonia, and 2692 from nephritis, nephrotic syndrome, or nephrosis. Compared with lifetime abstainers, current infrequent, light, or moderate drinkers were at a lower risk of mortality from all causes [infrequent—hazard ratio: 0.87; 95% confidence interval: 0.84 to 0.90; light: 0.77; 0.75 to 0.79; moderate 0.82; 0.80 to 0.85], CVD, chronic lower respiratory tract diseases, Alzheimer’s disease, and influenza and pneumonia. Also, light or moderate drinkers were associated with lower risk of mortality from diabetes mellitus and nephritis, nephrotic syndrome, or nephrosis. In contrast, heavy drinkers had a significantly higher risk of mortality from all causes, cancer, and accidents (unintentional injuries). Furthermore, binge drinking ≥ 1 day/week was associated with a higher risk of mortality from all causes (1.15; 1.09 to 1.22), cancer (1.22; 1.10 to 1.35), and accidents (unintentional injuries) (1.39; 1.11 to 1.74). Conclusions Infrequent, light, and moderate alcohol consumption were inversely associated with mortality from all causes, CVD, chronic lower respiratory tract diseases, Alzheimer’s disease, and influenza and pneumonia. Light or moderate alcohol consumption might also have a beneficial effect on mortality from diabetes mellitus and nephritis, nephrotic syndrome, or nephrosis. However, heavy or binge had a higher risk of all-cause, cancer, and accidents (unintentional injuries) mortality.https://doi.org/10.1186/s12916-023-02907-6AlcoholAll-cause mortalityCause-specific mortalityCardiovascular diseaseCancerChronic lower respiratory tract diseases |
| spellingShingle | Yalan Tian Jiahui Liu Yue Zhao Nana Jiang Xiao Liu Gang Zhao Xia Wang Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study BMC Medicine Alcohol All-cause mortality Cause-specific mortality Cardiovascular disease Cancer Chronic lower respiratory tract diseases |
| title | Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study |
| title_full | Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study |
| title_fullStr | Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study |
| title_full_unstemmed | Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study |
| title_short | Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study |
| title_sort | alcohol consumption and all cause and cause specific mortality among us adults prospective cohort study |
| topic | Alcohol All-cause mortality Cause-specific mortality Cardiovascular disease Cancer Chronic lower respiratory tract diseases |
| url | https://doi.org/10.1186/s12916-023-02907-6 |
| work_keys_str_mv | AT yalantian alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy AT jiahuiliu alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy AT yuezhao alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy AT nanajiang alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy AT xiaoliu alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy AT gangzhao alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy AT xiawang alcoholconsumptionandallcauseandcausespecificmortalityamongusadultsprospectivecohortstudy |