Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report
Kaposi sarcoma is relatively common after solid organ transplantation, but very rare after hematopoietic stem cell transplant (HSCT). Here we are reporting a rare case of Kaposi sarcoma in a child after HSCT. An 11-year-old boy with Fanconi anemia was treated by haploidentical HSCT from his father....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/2/188 |
| _version_ | 1797621717147844608 |
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| author | Mohammed Saud Alsaidan Ohoud Zaid Aljarbou Waleed Alajroush |
| author_facet | Mohammed Saud Alsaidan Ohoud Zaid Aljarbou Waleed Alajroush |
| author_sort | Mohammed Saud Alsaidan |
| collection | DOAJ |
| description | Kaposi sarcoma is relatively common after solid organ transplantation, but very rare after hematopoietic stem cell transplant (HSCT). Here we are reporting a rare case of Kaposi sarcoma in a child after HSCT. An 11-year-old boy with Fanconi anemia was treated by haploidentical HSCT from his father. Three weeks after transplantation, the patient developed severe graft-versus-host disease (GVHD) which was treated by immunosuppressive therapy and extracorporeal photopheresis. Approximately 6.5 months after HSCT, the patient had asymptomatic nodular skin lesions over the scalp, chest, and face. Histopathological examination showed typical findings of Kaposi sarcoma. Later, additional lesions in the liver and oral cavity were confirmed. Liver biopsy was positive for HHV-8 antibodies. The patient was continued on Sirolimus which was already being used for the treatment of GVHD. Cutaneous lesions were also treated with topical timolol 0.5% ophthalmic solution. Within six months, cutaneous and mucous membrane lesions were completely resolved. Follow-up abdominal ultrasound and MRI showed the disappearance of the hepatic lesion. |
| first_indexed | 2024-03-11T08:59:54Z |
| format | Article |
| id | doaj.art-5c42abe668254cbc869903552eb68120 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T08:59:54Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-5c42abe668254cbc869903552eb681202023-11-16T19:47:15ZengMDPI AGChildren2227-90672023-01-0110218810.3390/children10020188Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case ReportMohammed Saud Alsaidan0Ohoud Zaid Aljarbou1Waleed Alajroush2Internal Medicine Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi ArabiaConsultant Pathologist, Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaPediatric Dermatology, King Abdullah Specialized Children’s Hospital, Dermatology, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh 14611, Saudi ArabiaKaposi sarcoma is relatively common after solid organ transplantation, but very rare after hematopoietic stem cell transplant (HSCT). Here we are reporting a rare case of Kaposi sarcoma in a child after HSCT. An 11-year-old boy with Fanconi anemia was treated by haploidentical HSCT from his father. Three weeks after transplantation, the patient developed severe graft-versus-host disease (GVHD) which was treated by immunosuppressive therapy and extracorporeal photopheresis. Approximately 6.5 months after HSCT, the patient had asymptomatic nodular skin lesions over the scalp, chest, and face. Histopathological examination showed typical findings of Kaposi sarcoma. Later, additional lesions in the liver and oral cavity were confirmed. Liver biopsy was positive for HHV-8 antibodies. The patient was continued on Sirolimus which was already being used for the treatment of GVHD. Cutaneous lesions were also treated with topical timolol 0.5% ophthalmic solution. Within six months, cutaneous and mucous membrane lesions were completely resolved. Follow-up abdominal ultrasound and MRI showed the disappearance of the hepatic lesion.https://www.mdpi.com/2227-9067/10/2/188kaposi sarcomastem cell transplantfanconi anemiaSaudi Arabia |
| spellingShingle | Mohammed Saud Alsaidan Ohoud Zaid Aljarbou Waleed Alajroush Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report Children kaposi sarcoma stem cell transplant fanconi anemia Saudi Arabia |
| title | Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report |
| title_full | Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report |
| title_fullStr | Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report |
| title_full_unstemmed | Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report |
| title_short | Kaposi Sarcoma in a Child after Fanconi Anemia-Induced Haploidentical Hematopoietic Stem Cell Transplant: A Case Report |
| title_sort | kaposi sarcoma in a child after fanconi anemia induced haploidentical hematopoietic stem cell transplant a case report |
| topic | kaposi sarcoma stem cell transplant fanconi anemia Saudi Arabia |
| url | https://www.mdpi.com/2227-9067/10/2/188 |
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