Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF
Results from catheter ablation for persistent AF are suboptimal, with no strategy other than pulmonary vein isolation showing clear benefit. Recently employed empirical strategies beyond pulmonary vein isolation involve widespread atrial ablation in all patients and do not take into account patient-...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2022-05-01
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| Series: | Arrhythmia & Electrophysiology Review |
| Online Access: | https://www.aerjournal.com/articleindex/aer.2021.64 |
| _version_ | 1797199982742208512 |
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| author | Michael TB Pope Timothy R Betts |
| author_facet | Michael TB Pope Timothy R Betts |
| author_sort | Michael TB Pope |
| collection | DOAJ |
| description | Results from catheter ablation for persistent AF are suboptimal, with no strategy other than pulmonary vein isolation showing clear benefit. Recently employed empirical strategies beyond pulmonary vein isolation involve widespread atrial ablation in all patients and do not take into account patient-specific differences in AF mechanisms or phenotype. Charge density mapping using the non-contact AcQMap system (Acutus Medical) allows visualisation of whole-chamber activation during AF and reveals localised patterns of complex activation thought to represent important mechanisms for AF maintenance that can be targeted with focal ablation. In this review, the authors outline the fundamentals of this technology, the initial data exploring the mechanistic role of activation patterns seen and the application to ablation of persistent AF. |
| first_indexed | 2024-03-07T17:39:55Z |
| format | Article |
| id | doaj.art-5c42db05df7a47c4bc4a24eabe2b23ba |
| institution | Directory Open Access Journal |
| issn | 2050-3369 2050-3377 |
| language | English |
| last_indexed | 2024-04-24T07:24:24Z |
| publishDate | 2022-05-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Arrhythmia & Electrophysiology Review |
| spelling | doaj.art-5c42db05df7a47c4bc4a24eabe2b23ba2024-04-20T16:02:52ZengRadcliffe Medical MediaArrhythmia & Electrophysiology Review2050-33692050-33772022-05-011110.15420/aer.2021.64Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AFMichael TB Pope0Timothy R Betts1Department of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Department for Human Development and Health, University of Southampton, Southampton, UKDepartment of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; University of Oxford Biomedical Research Centre, Oxford, UKResults from catheter ablation for persistent AF are suboptimal, with no strategy other than pulmonary vein isolation showing clear benefit. Recently employed empirical strategies beyond pulmonary vein isolation involve widespread atrial ablation in all patients and do not take into account patient-specific differences in AF mechanisms or phenotype. Charge density mapping using the non-contact AcQMap system (Acutus Medical) allows visualisation of whole-chamber activation during AF and reveals localised patterns of complex activation thought to represent important mechanisms for AF maintenance that can be targeted with focal ablation. In this review, the authors outline the fundamentals of this technology, the initial data exploring the mechanistic role of activation patterns seen and the application to ablation of persistent AF.https://www.aerjournal.com/articleindex/aer.2021.64 |
| spellingShingle | Michael TB Pope Timothy R Betts Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF Arrhythmia & Electrophysiology Review |
| title | Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF |
| title_full | Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF |
| title_fullStr | Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF |
| title_full_unstemmed | Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF |
| title_short | Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF |
| title_sort | global substrate mapping and targeted ablation with novel gold tip catheter in de novo persistent af |
| url | https://www.aerjournal.com/articleindex/aer.2021.64 |
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