Admission Cardiac Troponins Predict Hospital Mortality in Type a Acute Aortic Dissection: a Meta-Analysis of Adjusted Risk Estimates
Acute aortic dissection (AAD) is a serious medical emergency that requires early diagnosis and rapid treatment. Whether cardiac troponin could be an independent prognostic marker in patients with type A AAD is still unknown. We systematically searched Medline and Scopus to identify all observatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2021-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/378051 |
| Summary: | Acute aortic dissection (AAD) is a serious medical emergency that requires early
diagnosis and rapid treatment. Whether cardiac troponin could be an independent prognostic marker
in patients with type A AAD is still unknown. We systematically searched Medline and Scopus to
identify all observational cohort studies published before January 2020 that compared outcome (inhospital
mortality) in patients with type A AAD with and without troponin elevation on admission.
Four studies with 412 patients were included in final analysis (median age 59 years, 65% of males). A
total of 124 (30%) patients died during in-hospital stay, and 73% underwent surgery. Elevated troponins
(39.6% of patients) were associated with an increased risk of short-term mortality (adjusted odds
ratio 1.26; 95% confidence interval 1.08-1.47), with low heterogeneity among studies (I2=29.81%).
Elevated troponins on admission are independently associated with increased in-hospital mortality in
type A AAD. |
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| ISSN: | 0353-9466 1333-9451 |