CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA
The aim of the study was to determine efficiency of Glutoxim, aimed for correction of immune disorders. The drug was administered to the patients with chronic cerebral ischemia (CCI, Stage I and II) complicated by arterial hypertension. Increased contents of pro- and anti-inflammatory cytokines, IFN...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2018-06-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1540 |
| _version_ | 1797197944984698880 |
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| author | A. A. Shulginova A. I. Konoplya N. A. Bystrova V. P. Gavriliuk A. V. Karaulov |
| author_facet | A. A. Shulginova A. I. Konoplya N. A. Bystrova V. P. Gavriliuk A. V. Karaulov |
| author_sort | A. A. Shulginova |
| collection | DOAJ |
| description | The aim of the study was to determine efficiency of Glutoxim, aimed for correction of immune disorders. The drug was administered to the patients with chronic cerebral ischemia (CCI, Stage I and II) complicated by arterial hypertension. Increased contents of pro- and anti-inflammatory cytokines, IFNγ, IL- 2, G-CSF, and activation of the complement system have been revealed for these conditions, at both functional stages of the disease. The patients with stage II CCI showed elevated markers of oxygen-dependent activity in polymorphonuclear leukocytes (increased levels of spontaneous and stimulated nitroblue tetrazolium (NBT) reduction tests, phagocytic capacity and stimulation index of neutrophils). Stage I of chronic cerebral ischemia was characterized by normal values of NBT reduction tests and functional reserve of neutrophils, along with decreased stimulation index of neutrophils. Among 26 parameters of immune status, 73.1% and 80.8% of indices proved to be changed, respectively, in the patients with stage I and II CCI. 66.7% of immune indices appeared similar in magnitude and direction of changes, whereas the resting 33% are identical in orientation. Usage of Cereton and Actovegin in treatment of the stage I CCI caused normalization of 5.3% immune parameters, with partial normalization of 26.3% tests, and 68.4% of the indexes remaining unchanged or increased posttreatment. Inclusion of Glutoxim into the combined pharmacotherapy proved to be more effective since it totally normalized 52.6% of the indexes, along with partial normalization of 21.1%, while 26.3% of the indicators were not affected by the therapy. Administration of Cereton and Actovegin at the second stage of chronic brain ischemia was followed by partial normalization for 47,6% of the tests, while leaving unchanged or increased 52.4% of the indicators. Glutoxim Use fully normalize 19.0% and partially normalizes 57.1% of immune parameters. |
| first_indexed | 2024-03-08T05:48:41Z |
| format | Article |
| id | doaj.art-5c43671e252d4288a5b4d1f3a21fa828 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:01Z |
| publishDate | 2018-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-5c43671e252d4288a5b4d1f3a21fa8282024-04-22T13:07:42ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2018-06-0120340141010.15789/1563-0625-2018-3-401-4101017CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIAA. A. Shulginova0A. I. Konoplya1N. A. Bystrova2V. P. Gavriliuk3A. V. Karaulov4Kursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityFirst Moscow I.M. Sechenov State Medical UniversityThe aim of the study was to determine efficiency of Glutoxim, aimed for correction of immune disorders. The drug was administered to the patients with chronic cerebral ischemia (CCI, Stage I and II) complicated by arterial hypertension. Increased contents of pro- and anti-inflammatory cytokines, IFNγ, IL- 2, G-CSF, and activation of the complement system have been revealed for these conditions, at both functional stages of the disease. The patients with stage II CCI showed elevated markers of oxygen-dependent activity in polymorphonuclear leukocytes (increased levels of spontaneous and stimulated nitroblue tetrazolium (NBT) reduction tests, phagocytic capacity and stimulation index of neutrophils). Stage I of chronic cerebral ischemia was characterized by normal values of NBT reduction tests and functional reserve of neutrophils, along with decreased stimulation index of neutrophils. Among 26 parameters of immune status, 73.1% and 80.8% of indices proved to be changed, respectively, in the patients with stage I and II CCI. 66.7% of immune indices appeared similar in magnitude and direction of changes, whereas the resting 33% are identical in orientation. Usage of Cereton and Actovegin in treatment of the stage I CCI caused normalization of 5.3% immune parameters, with partial normalization of 26.3% tests, and 68.4% of the indexes remaining unchanged or increased posttreatment. Inclusion of Glutoxim into the combined pharmacotherapy proved to be more effective since it totally normalized 52.6% of the indexes, along with partial normalization of 21.1%, while 26.3% of the indicators were not affected by the therapy. Administration of Cereton and Actovegin at the second stage of chronic brain ischemia was followed by partial normalization for 47,6% of the tests, while leaving unchanged or increased 52.4% of the indicators. Glutoxim Use fully normalize 19.0% and partially normalizes 57.1% of immune parameters.https://www.mimmun.ru/mimmun/article/view/1540сhronic cerebral ischemiaimmune disordersglutoximcytokinescomplement components |
| spellingShingle | A. A. Shulginova A. I. Konoplya N. A. Bystrova V. P. Gavriliuk A. V. Karaulov CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA Медицинская иммунология сhronic cerebral ischemia immune disorders glutoxim cytokines complement components |
| title | CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA |
| title_full | CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA |
| title_fullStr | CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA |
| title_full_unstemmed | CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA |
| title_short | CORRECTION OF IMMUNE DISTURBANCES IN CHRONIC CEREBRAL ISCHEMIA |
| title_sort | correction of immune disturbances in chronic cerebral ischemia |
| topic | сhronic cerebral ischemia immune disorders glutoxim cytokines complement components |
| url | https://www.mimmun.ru/mimmun/article/view/1540 |
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