Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report
Abstract Background The most common aetiological agents of mucormycosis are Rhizopus, Mucor, Apophysomyces and Lichtheimia. Apophysomyces is comparatively rare, as it has been reported in less than 3% of mucormycosis cases. The genus Apophysomyces includes six species, and only A. elegans, A. mexica...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05337-4 |
| _version_ | 1819110164502937600 |
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| author | Erick Martínez-Herrera María Guadalupe Frías-De-León Angélica Julián-Castrejón Luis Cruz-Benítez Juan Xicohtencatl-Cortes Rigoberto Hernández-Castro |
| author_facet | Erick Martínez-Herrera María Guadalupe Frías-De-León Angélica Julián-Castrejón Luis Cruz-Benítez Juan Xicohtencatl-Cortes Rigoberto Hernández-Castro |
| author_sort | Erick Martínez-Herrera |
| collection | DOAJ |
| description | Abstract Background The most common aetiological agents of mucormycosis are Rhizopus, Mucor, Apophysomyces and Lichtheimia. Apophysomyces is comparatively rare, as it has been reported in less than 3% of mucormycosis cases. The genus Apophysomyces includes six species, and only A. elegans, A. mexicanus, A. variabilis and A. ossiformis have been reported to cause infections in both immunocompetent and immunocompromised patients. Case presentation We present a case of a 46-year-old male patient with bilateral blepharoedema, corneal opacity in the left eye and poorly controlled diabetes mellitus. The patient was subjected to total maxillectomy, exenteration of the left orbit and treatment with liposomal amphotericin B. Direct mycological analysis with KOH 10% revealed hyaline, coenocytic, long and wide hyphae. Apophysomyces ossiformis was identified from maxillary biopsy using 18S-ITS1–5.8S-ITS2-28S rRNA gene amplification and sequencing. The patient requested to be transferred to another hospital to continue treatment, where he died on the ninth day after admittance. Conclusion To the best of our knowledge, this is the first case of rhino-orbital mucormycosis due to A. ossiformis with a fatal outcome. This case reveals the need to identify the fungus causing mucormycosis with molecular methods to identify adequate treatment therapies for patients with this infection. |
| first_indexed | 2024-12-22T03:37:22Z |
| format | Article |
| id | doaj.art-5c439969b3b94e2a9a2b7a058d22dce0 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-22T03:37:22Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-5c439969b3b94e2a9a2b7a058d22dce02022-12-21T18:40:21ZengBMCBMC Infectious Diseases1471-23342020-08-012011410.1186/s12879-020-05337-4Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case reportErick Martínez-Herrera0María Guadalupe Frías-De-León1Angélica Julián-Castrejón2Luis Cruz-Benítez3Juan Xicohtencatl-Cortes4Rigoberto Hernández-Castro5Hospital Regional de Alta Especialidad de IxtapalucaHospital Regional de Alta Especialidad de IxtapalucaHospital Regional de Alta Especialidad de IxtapalucaHospital Regional de Alta Especialidad de IxtapalucaLaboratorio de Bacteriología Intestinal, Hospital Infantil de México “Dr. Federico Gómez”Departamento de Ecología de Agentes Patógenos, Hospital General “Dr. Manuel Gea González”Abstract Background The most common aetiological agents of mucormycosis are Rhizopus, Mucor, Apophysomyces and Lichtheimia. Apophysomyces is comparatively rare, as it has been reported in less than 3% of mucormycosis cases. The genus Apophysomyces includes six species, and only A. elegans, A. mexicanus, A. variabilis and A. ossiformis have been reported to cause infections in both immunocompetent and immunocompromised patients. Case presentation We present a case of a 46-year-old male patient with bilateral blepharoedema, corneal opacity in the left eye and poorly controlled diabetes mellitus. The patient was subjected to total maxillectomy, exenteration of the left orbit and treatment with liposomal amphotericin B. Direct mycological analysis with KOH 10% revealed hyaline, coenocytic, long and wide hyphae. Apophysomyces ossiformis was identified from maxillary biopsy using 18S-ITS1–5.8S-ITS2-28S rRNA gene amplification and sequencing. The patient requested to be transferred to another hospital to continue treatment, where he died on the ninth day after admittance. Conclusion To the best of our knowledge, this is the first case of rhino-orbital mucormycosis due to A. ossiformis with a fatal outcome. This case reveals the need to identify the fungus causing mucormycosis with molecular methods to identify adequate treatment therapies for patients with this infection.http://link.springer.com/article/10.1186/s12879-020-05337-4Apophysomyces ossiformisDiabetes mellitusInvasive fungal diseaseMucormycosis |
| spellingShingle | Erick Martínez-Herrera María Guadalupe Frías-De-León Angélica Julián-Castrejón Luis Cruz-Benítez Juan Xicohtencatl-Cortes Rigoberto Hernández-Castro Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report BMC Infectious Diseases Apophysomyces ossiformis Diabetes mellitus Invasive fungal disease Mucormycosis |
| title | Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report |
| title_full | Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report |
| title_fullStr | Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report |
| title_full_unstemmed | Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report |
| title_short | Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report |
| title_sort | rhino orbital mucormycosis due to apophysomyces ossiformis in a patient with diabetes mellitus a case report |
| topic | Apophysomyces ossiformis Diabetes mellitus Invasive fungal disease Mucormycosis |
| url | http://link.springer.com/article/10.1186/s12879-020-05337-4 |
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