Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1800 |
| _version_ | 1797487171812196352 |
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| author | Yuwen Sun Manrui Li Shuqiang Cao Yang Xu Peiyan Wu Shuting Xu Qian Pan Yadong Guo Yi Ye Zheng Wang Hao Dai Xiaoqi Xie Xiameng Chen Weibo Liang |
| author_facet | Yuwen Sun Manrui Li Shuqiang Cao Yang Xu Peiyan Wu Shuting Xu Qian Pan Yadong Guo Yi Ye Zheng Wang Hao Dai Xiaoqi Xie Xiameng Chen Weibo Liang |
| author_sort | Yuwen Sun |
| collection | DOAJ |
| description | Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not without its own limitations. In this review, we narratively review the latest research on the improvement and existing challenges of optogenetics, with a particular focus on the field of brain injury, aiming at advancing optogenetics in the study of brain injury and collating the issues that remain. Finally, we review the most current examples of research, applying photostimulation in clinical treatment, and we explore the future prospects of these technologies. |
| first_indexed | 2024-03-09T23:43:47Z |
| format | Article |
| id | doaj.art-5c46dcca9e1d488eb7a8165e588b66e5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:43:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5c46dcca9e1d488eb7a8165e588b66e52023-11-23T16:46:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233180010.3390/ijms23031800Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future ProspectsYuwen Sun0Manrui Li1Shuqiang Cao2Yang Xu3Peiyan Wu4Shuting Xu5Qian Pan6Yadong Guo7Yi Ye8Zheng Wang9Hao Dai10Xiaoqi Xie11Xiameng Chen12Weibo Liang13West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, ChinaDepartment of Forensic Toxicological Analysis, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, ChinaInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of West China Clinical Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, ChinaOptogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not without its own limitations. In this review, we narratively review the latest research on the improvement and existing challenges of optogenetics, with a particular focus on the field of brain injury, aiming at advancing optogenetics in the study of brain injury and collating the issues that remain. Finally, we review the most current examples of research, applying photostimulation in clinical treatment, and we explore the future prospects of these technologies.https://www.mdpi.com/1422-0067/23/3/1800opsinstraumatic brain injuryneural circuitryneuronal apoptosisneuroregeneration |
| spellingShingle | Yuwen Sun Manrui Li Shuqiang Cao Yang Xu Peiyan Wu Shuting Xu Qian Pan Yadong Guo Yi Ye Zheng Wang Hao Dai Xiaoqi Xie Xiameng Chen Weibo Liang Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects International Journal of Molecular Sciences opsins traumatic brain injury neural circuitry neuronal apoptosis neuroregeneration |
| title | Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects |
| title_full | Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects |
| title_fullStr | Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects |
| title_full_unstemmed | Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects |
| title_short | Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects |
| title_sort | optogenetics for understanding and treating brain injury advances in the field and future prospects |
| topic | opsins traumatic brain injury neural circuitry neuronal apoptosis neuroregeneration |
| url | https://www.mdpi.com/1422-0067/23/3/1800 |
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