Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy?
Dilated cardiomyopathy (DCM) is the most prevalent cardiomyopathy, typified by left ventricular dilation and systolic dysfunction. Many patients with DCM have altered thyroid status, especially lower levels of free triiodothyronine (T3) and elevated levels of thyroid-stimulating hormone. Moreover, g...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/16/3618 |
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| author | Karolina Zawadzka Radosław Dziedzic Andrzej Surdacki Bernadeta Chyrchel |
| author_facet | Karolina Zawadzka Radosław Dziedzic Andrzej Surdacki Bernadeta Chyrchel |
| author_sort | Karolina Zawadzka |
| collection | DOAJ |
| description | Dilated cardiomyopathy (DCM) is the most prevalent cardiomyopathy, typified by left ventricular dilation and systolic dysfunction. Many patients with DCM have altered thyroid status, especially lower levels of free triiodothyronine (T3) and elevated levels of thyroid-stimulating hormone. Moreover, growing evidence indicates that even subtle changes in thyroid status (especially low T3) are linked with a worse long-term prognosis and a higher risk of mortality. Notably, recent discoveries have shown that not only local myocardial thyroid hormones (THs) bioavailability could be diminished due to impaired expression of the activating deiodinase, but virtually all genes involved in TH biosynthesis are also expressed in the myocardium of DCM patients. Importantly, some studies have suggested beneficial effects of TH therapy in patients suffering from DCM. Our aim was to discuss new insights into the association between TH status and prognosis in DCM, abnormal expression of genes involved in the myocardial synthesis of TH in DCM, and the potential for TH use in the future treatment of DCM. |
| first_indexed | 2024-03-10T08:41:54Z |
| format | Article |
| id | doaj.art-5c4a2547eb8841ad8136f3991f558470 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:41:54Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5c4a2547eb8841ad8136f3991f5584702023-11-22T08:11:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011016361810.3390/jcm10163618Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy?Karolina Zawadzka0Radosław Dziedzic1Andrzej Surdacki2Bernadeta Chyrchel3Students’ Scientific Group at the Second Department of Cardiology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 30-688 Cracow, PolandStudents’ Scientific Group at the Second Department of Cardiology, Jagiellonian University Medical College, 2 Jakubowskiego Street, 30-688 Cracow, PolandSecond Department of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 2 Jakubowskiego Street, 30-688 Cracow, PolandSecond Department of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 2 Jakubowskiego Street, 30-688 Cracow, PolandDilated cardiomyopathy (DCM) is the most prevalent cardiomyopathy, typified by left ventricular dilation and systolic dysfunction. Many patients with DCM have altered thyroid status, especially lower levels of free triiodothyronine (T3) and elevated levels of thyroid-stimulating hormone. Moreover, growing evidence indicates that even subtle changes in thyroid status (especially low T3) are linked with a worse long-term prognosis and a higher risk of mortality. Notably, recent discoveries have shown that not only local myocardial thyroid hormones (THs) bioavailability could be diminished due to impaired expression of the activating deiodinase, but virtually all genes involved in TH biosynthesis are also expressed in the myocardium of DCM patients. Importantly, some studies have suggested beneficial effects of TH therapy in patients suffering from DCM. Our aim was to discuss new insights into the association between TH status and prognosis in DCM, abnormal expression of genes involved in the myocardial synthesis of TH in DCM, and the potential for TH use in the future treatment of DCM.https://www.mdpi.com/2077-0383/10/16/3618dilated cardiomyopathythyroid hormonesthyroid statusprognosistreatment |
| spellingShingle | Karolina Zawadzka Radosław Dziedzic Andrzej Surdacki Bernadeta Chyrchel Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy? Journal of Clinical Medicine dilated cardiomyopathy thyroid hormones thyroid status prognosis treatment |
| title | Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy? |
| title_full | Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy? |
| title_fullStr | Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy? |
| title_full_unstemmed | Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy? |
| title_short | Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy? |
| title_sort | thyroid hormones an underestimated player in dilated cardiomyopathy |
| topic | dilated cardiomyopathy thyroid hormones thyroid status prognosis treatment |
| url | https://www.mdpi.com/2077-0383/10/16/3618 |
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