Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery
This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of differen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2020.1858998 |
| _version_ | 1818987170239610880 |
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| author | Lianlian Cao Guojing Shao Fengmei Ren Minghua Yang Yan Nie Qian Peng Peng Zhang |
| author_facet | Lianlian Cao Guojing Shao Fengmei Ren Minghua Yang Yan Nie Qian Peng Peng Zhang |
| author_sort | Lianlian Cao |
| collection | DOAJ |
| description | This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from ∼10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be ∼38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future. |
| first_indexed | 2024-12-20T19:02:26Z |
| format | Article |
| id | doaj.art-5c4d7fdd9bf9446cb14a4d483efb99b1 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-20T19:02:26Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-5c4d7fdd9bf9446cb14a4d483efb99b12022-12-21T19:29:22ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642021-01-0128139039910.1080/10717544.2020.18589981858998Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgeryLianlian Cao0Guojing Shao1Fengmei Ren2Minghua Yang3Yan Nie4Qian Peng5Peng Zhang6Emergency Department, Dongying People’s HospitalEmergency Department, Dongying People’s HospitalPsychiatry Department, Dongying Rongjun HospitalHealth Care Department, Dongying People’s HospitalEmergency Department, Dongying People’s HospitalEmergency Department, Dongying People’s HospitalEmergency Department, Dongying People’s HospitalThis study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from ∼10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be ∼38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.http://dx.doi.org/10.1080/10717544.2020.1858998cerium nanogelspolyvinyl alcoholwound healingin vivo mouse model |
| spellingShingle | Lianlian Cao Guojing Shao Fengmei Ren Minghua Yang Yan Nie Qian Peng Peng Zhang Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery Drug Delivery cerium nanogels polyvinyl alcohol wound healing in vivo mouse model |
| title | Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery |
| title_full | Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery |
| title_fullStr | Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery |
| title_full_unstemmed | Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery |
| title_short | Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery |
| title_sort | cerium oxide nanoparticle loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery |
| topic | cerium nanogels polyvinyl alcohol wound healing in vivo mouse model |
| url | http://dx.doi.org/10.1080/10717544.2020.1858998 |
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