Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review
The skin often reflects the presence of internal diseases. Acrokeratosis neoplastica (Bazex syndrome) is a unique skin manifestation characterized by its erythematous hyperkeratosis with yellowish, adherent scales on the palm, sole, or other acral locations. There is a potentially high association b...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024024423 |
| _version_ | 1797259857587339264 |
|---|---|
| author | Atsushi Yamada Naoka Umemoto Toshio Demitsu Osamu Kitamura |
| author_facet | Atsushi Yamada Naoka Umemoto Toshio Demitsu Osamu Kitamura |
| author_sort | Atsushi Yamada |
| collection | DOAJ |
| description | The skin often reflects the presence of internal diseases. Acrokeratosis neoplastica (Bazex syndrome) is a unique skin manifestation characterized by its erythematous hyperkeratosis with yellowish, adherent scales on the palm, sole, or other acral locations. There is a potentially high association between Bazex syndrome and malignant pathology, especially squamous cell carcinomas (SCC). To date, various skin conditions have been recognized as diagnostic indicators of insidious malignancies. The recognition of paraneoplastic dermatoses has a strong potential for prompt cancer detection and early therapeutic intervention. Here we describe clinical and forensic cases of Bazex syndrome that are associated with SCC of the glottis and lung. Bazex syndrome has been reported to be associated with a variety of cancers in addition to SCC. We review the clinical manifestations of Bazex syndrome and include updated knowledge on disease pathogenesis. |
| first_indexed | 2024-03-07T21:53:13Z |
| format | Article |
| id | doaj.art-5c4dc5a08ee848afab37342ac0d1862c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:16:06Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-5c4dc5a08ee848afab37342ac0d1862c2024-03-17T07:55:27ZengElsevierHeliyon2405-84402024-03-01105e26411Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature reviewAtsushi Yamada0Naoka Umemoto1Toshio Demitsu2Osamu Kitamura3Department of Legal Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan; Department of Dermatology, Jichi Medical University Saitama Medical Center, 1-847, Amanuma-cho, Omiya-ku, Saitama, 330-0834, Japan; Corresponding author. Department of Legal Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.Department of Dermatology, Jichi Medical University Saitama Medical Center, 1-847, Amanuma-cho, Omiya-ku, Saitama, 330-0834, JapanDepartment of Dermatology, Jichi Medical University Saitama Medical Center, 1-847, Amanuma-cho, Omiya-ku, Saitama, 330-0834, JapanDepartment of Legal Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo, 181-8611, JapanThe skin often reflects the presence of internal diseases. Acrokeratosis neoplastica (Bazex syndrome) is a unique skin manifestation characterized by its erythematous hyperkeratosis with yellowish, adherent scales on the palm, sole, or other acral locations. There is a potentially high association between Bazex syndrome and malignant pathology, especially squamous cell carcinomas (SCC). To date, various skin conditions have been recognized as diagnostic indicators of insidious malignancies. The recognition of paraneoplastic dermatoses has a strong potential for prompt cancer detection and early therapeutic intervention. Here we describe clinical and forensic cases of Bazex syndrome that are associated with SCC of the glottis and lung. Bazex syndrome has been reported to be associated with a variety of cancers in addition to SCC. We review the clinical manifestations of Bazex syndrome and include updated knowledge on disease pathogenesis.http://www.sciencedirect.com/science/article/pii/S2405844024024423Acrokeratosis neoplasticaBazex syndromeParaneoplastic dermatosisSquamous cell carcinomaCase report |
| spellingShingle | Atsushi Yamada Naoka Umemoto Toshio Demitsu Osamu Kitamura Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review Heliyon Acrokeratosis neoplastica Bazex syndrome Paraneoplastic dermatosis Squamous cell carcinoma Case report |
| title | Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review |
| title_full | Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review |
| title_fullStr | Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review |
| title_full_unstemmed | Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review |
| title_short | Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review |
| title_sort | acrokeratosis neoplastica bazex syndrome report of two cases and literature review |
| topic | Acrokeratosis neoplastica Bazex syndrome Paraneoplastic dermatosis Squamous cell carcinoma Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024024423 |
| work_keys_str_mv | AT atsushiyamada acrokeratosisneoplasticabazexsyndromereportoftwocasesandliteraturereview AT naokaumemoto acrokeratosisneoplasticabazexsyndromereportoftwocasesandliteraturereview AT toshiodemitsu acrokeratosisneoplasticabazexsyndromereportoftwocasesandliteraturereview AT osamukitamura acrokeratosisneoplasticabazexsyndromereportoftwocasesandliteraturereview |