SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies
Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/2/168 |
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| author | Hongyu Liu Yang Zhao Guizhen Zhao Yongjie Deng Y. Eugene Chen Jifeng Zhang |
| author_facet | Hongyu Liu Yang Zhao Guizhen Zhao Yongjie Deng Y. Eugene Chen Jifeng Zhang |
| author_sort | Hongyu Liu |
| collection | DOAJ |
| description | Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal role in orchestrating chromatin conformation, which is critical for gene regulation. In this review, we provide a summary of research related to the involvement of the SWI/SNF complexes in VSMC and cardiovascular diseases (CVD), integrating these discoveries into the current landscape of epigenetic and transcriptional regulation in VSMC. These novel discoveries shed light on our understanding of VSMC biology and pave the way for developing innovative therapeutic strategies in CVD treatment. |
| first_indexed | 2024-03-08T09:55:46Z |
| format | Article |
| id | doaj.art-5c4ecc0a599a45c7b44c6e9388c90728 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T09:55:46Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5c4ecc0a599a45c7b44c6e9388c907282024-01-29T13:50:31ZengMDPI AGCells2073-44092024-01-0113216810.3390/cells13020168SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular PathologiesHongyu Liu0Yang Zhao1Guizhen Zhao2Yongjie Deng3Y. Eugene Chen4Jifeng Zhang5Department of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USADepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USADepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USADepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USADepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USADepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USAMature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal role in orchestrating chromatin conformation, which is critical for gene regulation. In this review, we provide a summary of research related to the involvement of the SWI/SNF complexes in VSMC and cardiovascular diseases (CVD), integrating these discoveries into the current landscape of epigenetic and transcriptional regulation in VSMC. These novel discoveries shed light on our understanding of VSMC biology and pave the way for developing innovative therapeutic strategies in CVD treatment.https://www.mdpi.com/2073-4409/13/2/168vascular smooth muscle cellSWI/SNF complexepigeneticscardiovascular disease |
| spellingShingle | Hongyu Liu Yang Zhao Guizhen Zhao Yongjie Deng Y. Eugene Chen Jifeng Zhang SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies Cells vascular smooth muscle cell SWI/SNF complex epigenetics cardiovascular disease |
| title | SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies |
| title_full | SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies |
| title_fullStr | SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies |
| title_full_unstemmed | SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies |
| title_short | SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies |
| title_sort | swi snf complex in vascular smooth muscle cells and its implications in cardiovascular pathologies |
| topic | vascular smooth muscle cell SWI/SNF complex epigenetics cardiovascular disease |
| url | https://www.mdpi.com/2073-4409/13/2/168 |
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