NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
<b>Background:</b> Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information...
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/381 |
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| author | J. Tyson McDonald Robert Stainforth Jack Miller Thomas Cahill Willian A. da Silveira Komal S. Rathi Gary Hardiman Deanne Taylor Sylvain V. Costes Vinita Chauhan Robert Meller Afshin Beheshti |
| author_facet | J. Tyson McDonald Robert Stainforth Jack Miller Thomas Cahill Willian A. da Silveira Komal S. Rathi Gary Hardiman Deanne Taylor Sylvain V. Costes Vinita Chauhan Robert Meller Afshin Beheshti |
| author_sort | J. Tyson McDonald |
| collection | DOAJ |
| description | <b>Background:</b> Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. <b>Methods:</b> We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. <b>Results:</b> From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. <b>Conclusions:</b> We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures. |
| first_indexed | 2024-03-12T05:54:26Z |
| format | Article |
| id | doaj.art-5c4efb29f4514b938bec5566a46704a2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:54:26Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5c4efb29f4514b938bec5566a46704a22023-09-03T04:46:44ZengMDPI AGCancers2072-66942020-02-0112238110.3390/cancers12020381cancers12020381NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal ModelsJ. Tyson McDonald0Robert Stainforth1Jack Miller2Thomas Cahill3Willian A. da Silveira4Komal S. Rathi5Gary Hardiman6Deanne Taylor7Sylvain V. Costes8Vinita Chauhan9Robert Meller10Afshin Beheshti11RadBioX Services LLC, Okemos, MI 48864, USAConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON K1A-1C1, CanadaKBR, NASA Ames Research Center, Moffett Field, CA 94035, USASchool of Biological Sciences & Institute for Global Food Security, Queens University Belfast, Belfast BT9 5DL, UKSchool of Biological Sciences & Institute for Global Food Security, Queens University Belfast, Belfast BT9 5DL, UKDepartment of Biomedical Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USASchool of Biological Sciences & Institute for Global Food Security, Queens University Belfast, Belfast BT9 5DL, UKDepartment of Biomedical Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USANASA Ames Research Center, Space Biosciences Division, Moffett Field, CA 94035, USAConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON K1A-1C1, CanadaDepartment of Neurobiology and Pharmacology, Morehouse School of Medicine, Atlanta, GA 30310, USAKBR, NASA Ames Research Center, Moffett Field, CA 94035, USA<b>Background:</b> Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. <b>Methods:</b> We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. <b>Results:</b> From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. <b>Conclusions:</b> We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.https://www.mdpi.com/2072-6694/12/2/381genelabnasaspace radiationhzegalactic cosmic raystranscriptomicsdosimetryradiation |
| spellingShingle | J. Tyson McDonald Robert Stainforth Jack Miller Thomas Cahill Willian A. da Silveira Komal S. Rathi Gary Hardiman Deanne Taylor Sylvain V. Costes Vinita Chauhan Robert Meller Afshin Beheshti NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models Cancers genelab nasa space radiation hze galactic cosmic rays transcriptomics dosimetry radiation |
| title | NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models |
| title_full | NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models |
| title_fullStr | NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models |
| title_full_unstemmed | NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models |
| title_short | NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models |
| title_sort | nasa genelab platform utilized for biological response to space radiation in animal models |
| topic | genelab nasa space radiation hze galactic cosmic rays transcriptomics dosimetry radiation |
| url | https://www.mdpi.com/2072-6694/12/2/381 |
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