A p53-Pax2 pathway in kidney development: implications for nephrogenesis.

A p53-Pax2 pathway in kidney development: implications for nephrogenesis.

Congenital reduction in nephron number (renal hypoplasia) is a predisposing factor for chronic kidney disease and hypertension. Despite identification of specific genes and pathways in nephrogenesis, determinants of final nephron endowment are poorly understood. Here, we report that mice with germ-l...

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Bibliographic Details
Main Authors: Zubaida Saifudeen, Jiao Liu, Susana Dipp, Xiao Yao, Yuwen Li, Nathaniel McLaughlin, Karam Aboudehen, Samir S El-Dahr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3440354?pdf=render

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