Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease
Subjective cognitive complaints (SCCs), defined as cognitive decline reported by subjects or their informants, are common in the early stage of Parkinson's disease (PD). Previous studies have shown a significant association between SCCs and non-motor features as well as objective cognitive decl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1257799/full |
| _version_ | 1797427114227531776 |
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| author | Juan Huang Lin Chen Binbin Hu Hui Wang Xinyue Zhang Xingfu Tian Shu Wang Wei Huang |
| author_facet | Juan Huang Lin Chen Binbin Hu Hui Wang Xinyue Zhang Xingfu Tian Shu Wang Wei Huang |
| author_sort | Juan Huang |
| collection | DOAJ |
| description | Subjective cognitive complaints (SCCs), defined as cognitive decline reported by subjects or their informants, are common in the early stage of Parkinson's disease (PD). Previous studies have shown a significant association between SCCs and non-motor features as well as objective cognitive decline in PD patients. However, the discrepancy in SCC prevalence and SCC-related factors between patients with early PD and those with advanced PD remains poorly understood. We recruited a total of 114 and 69 early PD patients and advanced PD patients, respectively. Univariate and multivariate logistic regression analyses were performed for early PD and advanced PD patients. The prevalence of SCCs in the early PD and advanced PD groups was 60.5 and 68.1%, respectively. In the early PD group, the presence of SCCs in early PD participants was significantly associated with a higher nonmotor symptoms questionnaire (NMSQ) score (OR = 1.05, 95% CI = 1.00–1.10, p = 0.040). SCCs in the advanced PD group were related to lower attention scores (OR = 0.24, 95% CI = 0.05–0.90, p = 0.043) and lower visuospatial/executive abilities scores (OR = 0.18, 95% CI = 0.04–0.86, p = 0.032). The prevalence and SCC-related factors are distinct in early PD and advanced PD. These findings suggest that SCCs in PD patients with different disease statuses appear to have different related factors that may depend on different disease severities. |
| first_indexed | 2024-03-09T08:39:52Z |
| format | Article |
| id | doaj.art-5c523ed753a94ef989588dd6d6a3086a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-09T08:39:52Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5c523ed753a94ef989588dd6d6a3086a2023-12-02T17:06:46ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-12-011510.3389/fnagi.2023.12577991257799Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's diseaseJuan Huang0Lin Chen1Binbin Hu2Hui Wang3Xinyue Zhang4Xingfu Tian5Shu Wang6Wei Huang7Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Intensive Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, ChinaSubjective cognitive complaints (SCCs), defined as cognitive decline reported by subjects or their informants, are common in the early stage of Parkinson's disease (PD). Previous studies have shown a significant association between SCCs and non-motor features as well as objective cognitive decline in PD patients. However, the discrepancy in SCC prevalence and SCC-related factors between patients with early PD and those with advanced PD remains poorly understood. We recruited a total of 114 and 69 early PD patients and advanced PD patients, respectively. Univariate and multivariate logistic regression analyses were performed for early PD and advanced PD patients. The prevalence of SCCs in the early PD and advanced PD groups was 60.5 and 68.1%, respectively. In the early PD group, the presence of SCCs in early PD participants was significantly associated with a higher nonmotor symptoms questionnaire (NMSQ) score (OR = 1.05, 95% CI = 1.00–1.10, p = 0.040). SCCs in the advanced PD group were related to lower attention scores (OR = 0.24, 95% CI = 0.05–0.90, p = 0.043) and lower visuospatial/executive abilities scores (OR = 0.18, 95% CI = 0.04–0.86, p = 0.032). The prevalence and SCC-related factors are distinct in early PD and advanced PD. These findings suggest that SCCs in PD patients with different disease statuses appear to have different related factors that may depend on different disease severities.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1257799/fullearly Parkinson's diseaseadvanced Parkinson's diseasesubjective cognitive complaintsnonmotor symptomsattention |
| spellingShingle | Juan Huang Lin Chen Binbin Hu Hui Wang Xinyue Zhang Xingfu Tian Shu Wang Wei Huang Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease Frontiers in Aging Neuroscience early Parkinson's disease advanced Parkinson's disease subjective cognitive complaints nonmotor symptoms attention |
| title | Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease |
| title_full | Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease |
| title_fullStr | Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease |
| title_full_unstemmed | Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease |
| title_short | Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease |
| title_sort | different associated factors of subjective cognitive complaints in patients with early and advanced parkinson s disease |
| topic | early Parkinson's disease advanced Parkinson's disease subjective cognitive complaints nonmotor symptoms attention |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1257799/full |
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