Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice
Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine and oxidative stress in mice. The antiepileptic potential of DVS (10, 20, or 30 mg/kg/i.p.) in pen...
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| Format: | Article |
| Language: | English |
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Instituto Internacional de Ecologia
2021-08-01
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| Series: | Brazilian Journal of Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100180&tlng=en |
| _version_ | 1819285077403631616 |
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| author | Khalid Saad Alharbi |
| author_facet | Khalid Saad Alharbi |
| author_sort | Khalid Saad Alharbi |
| collection | DOAJ |
| description | Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine and oxidative stress in mice. The antiepileptic potential of DVS (10, 20, or 30 mg/kg/i.p.) in pentylenetetrazole (PTZ; 85 mg/kg) with i.p. route of administration, strychnine (STR; 75 mg/kg) with i.p. route, pilocarpine (400 mg/kg) with s.c. route and maximal electroshock MES-induced convulsion in mouse models. The activities of oxidative stress, i.e. superoxide dismutase (SOD), glutathione (GSH) and lipid peroxidation (LPO) as well as gamma-aminobutyric acid (GABA) in the brains of PTZ-induced convulsive mice. Treatment with DVS increased the latency to develop siezures and declined mortalities in rodents against PTZ, STR and pilocarpine-induced convulsions. Results of MES-leaded siezures revealed that DVS reduced tonic hind limb extension duration and mortalities significantly. Brain, SOD, GSH and GABA level were significantly (P<0.01) increased and LPO reduced significantly (P<0.01) after DVS treatment. Furthermore, the DVS did not show any motor coordination signs in the rotarod test. We demonstrated that the role of DVS in convulsion genesis in mice under control condition and attenuate the PTZ-induced oxidative damage. |
| first_indexed | 2024-12-24T01:57:32Z |
| format | Article |
| id | doaj.art-5c5442a17c39423ca3165ff40f7106ea |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-12-24T01:57:32Z |
| publishDate | 2021-08-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-5c5442a17c39423ca3165ff40f7106ea2022-12-21T17:21:32ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752021-08-018310.1590/1519-6984.246194Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in miceKhalid Saad Alharbihttps://orcid.org/0000-0003-0393-1890Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine and oxidative stress in mice. The antiepileptic potential of DVS (10, 20, or 30 mg/kg/i.p.) in pentylenetetrazole (PTZ; 85 mg/kg) with i.p. route of administration, strychnine (STR; 75 mg/kg) with i.p. route, pilocarpine (400 mg/kg) with s.c. route and maximal electroshock MES-induced convulsion in mouse models. The activities of oxidative stress, i.e. superoxide dismutase (SOD), glutathione (GSH) and lipid peroxidation (LPO) as well as gamma-aminobutyric acid (GABA) in the brains of PTZ-induced convulsive mice. Treatment with DVS increased the latency to develop siezures and declined mortalities in rodents against PTZ, STR and pilocarpine-induced convulsions. Results of MES-leaded siezures revealed that DVS reduced tonic hind limb extension duration and mortalities significantly. Brain, SOD, GSH and GABA level were significantly (P<0.01) increased and LPO reduced significantly (P<0.01) after DVS treatment. Furthermore, the DVS did not show any motor coordination signs in the rotarod test. We demonstrated that the role of DVS in convulsion genesis in mice under control condition and attenuate the PTZ-induced oxidative damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100180&tlng=enanticonvulsant effectDesvenlafaxineoxidative stressPentylenetetrazol |
| spellingShingle | Khalid Saad Alharbi Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice Brazilian Journal of Biology anticonvulsant effect Desvenlafaxine oxidative stress Pentylenetetrazol |
| title | Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice |
| title_full | Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice |
| title_fullStr | Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice |
| title_full_unstemmed | Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice |
| title_short | Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice |
| title_sort | anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice |
| topic | anticonvulsant effect Desvenlafaxine oxidative stress Pentylenetetrazol |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100180&tlng=en |
| work_keys_str_mv | AT khalidsaadalharbi anticonvulsanteffectsofdesvenlafaxineonmodulatingbrainmonoamineandoxidativestressinmice |