The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses
<i>Background and Objectives</i>: Previous studies revealed the anti-angiogenic, antiproliferative, and anti-inflammatory effects of Vitamin D (VitD) on cancer cells. Although this body of evidence supported the correlation of high VitD levels with reduced incidence rates for various mal...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/12/2130 |
| _version_ | 1797380124825354240 |
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| author | Konstantinos Seretis Nikolaos Bounas Chrissa Sioka |
| author_facet | Konstantinos Seretis Nikolaos Bounas Chrissa Sioka |
| author_sort | Konstantinos Seretis |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Previous studies revealed the anti-angiogenic, antiproliferative, and anti-inflammatory effects of Vitamin D (VitD) on cancer cells. Although this body of evidence supported the correlation of high VitD levels with reduced incidence rates for various malignancies, contradictory results were reported regarding non-melanoma skin cancer (NMSC). The aim of this overview was to summarize the available evidence from the existing pool of systematic reviews and meta-analyses, focusing on VitD serum status, dietary intake, and VitD receptor (VDR) polymorphisms in correlation to NMSC incidence. <i>Materials and Methods</i>: A literature search in electronic databases was conducted from inception to January 2023. The inclusion criteria were systematic reviews and meta-analyses published in peer-reviewed journals, evaluating VitD serum levels, dietary and/or supplementary intake, or VDR gene polymorphisms, and reporting data on NMSC. <i>Results:</i> A total of 10 studies were included in the data analysis models. A positive association between VitD serum levels and NMSC is highlighted. However, dietary/supplementation of VitD does not exhibit a likewise strong linkage to NMSC. Despite the contradictory findings, VDR polymorphisms may play a crucial role in the intricate NMSC pathogenesis. <i>Conclusions:</i> This umbrella review shows that high VitD levels are associated with increased NMSC incidence, potentially due to its direct correlation with increased sun exposure. Further research on VDR polymorphisms is suggested to explore their true effect size on NMSC risk. |
| first_indexed | 2024-03-08T20:32:47Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T20:32:47Z |
| publishDate | 2023-12-01 |
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| series | Medicina |
| spelling | doaj.art-5c555aa88eae403bb535fe3de67fe5f32023-12-22T14:23:54ZengMDPI AGMedicina1010-660X1648-91442023-12-015912213010.3390/medicina59122130The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-AnalysesKonstantinos Seretis0Nikolaos Bounas1Chrissa Sioka2Department of Plastic Surgery, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Plastic Surgery, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Nuclear Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece<i>Background and Objectives</i>: Previous studies revealed the anti-angiogenic, antiproliferative, and anti-inflammatory effects of Vitamin D (VitD) on cancer cells. Although this body of evidence supported the correlation of high VitD levels with reduced incidence rates for various malignancies, contradictory results were reported regarding non-melanoma skin cancer (NMSC). The aim of this overview was to summarize the available evidence from the existing pool of systematic reviews and meta-analyses, focusing on VitD serum status, dietary intake, and VitD receptor (VDR) polymorphisms in correlation to NMSC incidence. <i>Materials and Methods</i>: A literature search in electronic databases was conducted from inception to January 2023. The inclusion criteria were systematic reviews and meta-analyses published in peer-reviewed journals, evaluating VitD serum levels, dietary and/or supplementary intake, or VDR gene polymorphisms, and reporting data on NMSC. <i>Results:</i> A total of 10 studies were included in the data analysis models. A positive association between VitD serum levels and NMSC is highlighted. However, dietary/supplementation of VitD does not exhibit a likewise strong linkage to NMSC. Despite the contradictory findings, VDR polymorphisms may play a crucial role in the intricate NMSC pathogenesis. <i>Conclusions:</i> This umbrella review shows that high VitD levels are associated with increased NMSC incidence, potentially due to its direct correlation with increased sun exposure. Further research on VDR polymorphisms is suggested to explore their true effect size on NMSC risk.https://www.mdpi.com/1648-9144/59/12/2130non-melanoma skin cancervitamin Driskvitamin D receptorreviewVDR polymorphism |
| spellingShingle | Konstantinos Seretis Nikolaos Bounas Chrissa Sioka The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses Medicina non-melanoma skin cancer vitamin D risk vitamin D receptor review VDR polymorphism |
| title | The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses |
| title_full | The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses |
| title_fullStr | The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses |
| title_full_unstemmed | The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses |
| title_short | The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses |
| title_sort | association of vitamin d with non melanoma skin cancer risk an umbrella review of systematic reviews and meta analyses |
| topic | non-melanoma skin cancer vitamin D risk vitamin D receptor review VDR polymorphism |
| url | https://www.mdpi.com/1648-9144/59/12/2130 |
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