Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning
Brain-wide activities revealed by neuroimaging and recording techniques have been used to predict motor and cognitive functions in both human and animal models. However, although studies have shown the existence of micrometer-scale spatial organization of neurons in the motor cortex relevant to moto...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00088/full |
| _version_ | 1818215490417328128 |
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| author | Chunyue Li Danny C. W. Chan Xiaofeng Yang Ya Ke Wing-Ho Yung |
| author_facet | Chunyue Li Danny C. W. Chan Xiaofeng Yang Ya Ke Wing-Ho Yung |
| author_sort | Chunyue Li |
| collection | DOAJ |
| description | Brain-wide activities revealed by neuroimaging and recording techniques have been used to predict motor and cognitive functions in both human and animal models. However, although studies have shown the existence of micrometer-scale spatial organization of neurons in the motor cortex relevant to motor control, two-photon microscopy (TPM) calcium imaging at cellular resolution has not been fully exploited for the same purpose. Here, we ask if calcium imaging data recorded by TPM in rodent brain can provide enough information to predict features of upcoming movement. We collected calcium imaging signal from rostral forelimb area in layer 2/3 of the motor cortex while mice performed a two-dimensional lever reaching task. Images of average calcium activity collected during motion preparation period and inter-trial interval (ITI) were used to predict the forelimb reach results. The evaluation was based on a deep learning model that had been applied for object recognition. We found that the prediction accuracy for both maximum reaching location and trial outcome based on motion preparation period but not ITI were higher than the probabilities governed by chance. Our study demonstrated that imaging data encompassing information on the spatial organization of functional neuronal clusters in the motor cortex is useful in predicting motor acts even in the absence of detailed dynamics of neural activities. |
| first_indexed | 2024-12-12T06:36:54Z |
| format | Article |
| id | doaj.art-5c55e374aa7c4d9b8990d1f591112db8 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T06:36:54Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-5c55e374aa7c4d9b8990d1f591112db82022-12-22T00:34:27ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-03-011310.3389/fncel.2019.00088427470Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep LearningChunyue LiDanny C. W. ChanXiaofeng YangYa KeWing-Ho YungBrain-wide activities revealed by neuroimaging and recording techniques have been used to predict motor and cognitive functions in both human and animal models. However, although studies have shown the existence of micrometer-scale spatial organization of neurons in the motor cortex relevant to motor control, two-photon microscopy (TPM) calcium imaging at cellular resolution has not been fully exploited for the same purpose. Here, we ask if calcium imaging data recorded by TPM in rodent brain can provide enough information to predict features of upcoming movement. We collected calcium imaging signal from rostral forelimb area in layer 2/3 of the motor cortex while mice performed a two-dimensional lever reaching task. Images of average calcium activity collected during motion preparation period and inter-trial interval (ITI) were used to predict the forelimb reach results. The evaluation was based on a deep learning model that had been applied for object recognition. We found that the prediction accuracy for both maximum reaching location and trial outcome based on motion preparation period but not ITI were higher than the probabilities governed by chance. Our study demonstrated that imaging data encompassing information on the spatial organization of functional neuronal clusters in the motor cortex is useful in predicting motor acts even in the absence of detailed dynamics of neural activities.https://www.frontiersin.org/article/10.3389/fncel.2019.00088/fullmotor cortextwo-photon imagingmovement predictiondeep learningconvolutional neural network |
| spellingShingle | Chunyue Li Danny C. W. Chan Xiaofeng Yang Ya Ke Wing-Ho Yung Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning Frontiers in Cellular Neuroscience motor cortex two-photon imaging movement prediction deep learning convolutional neural network |
| title | Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning |
| title_full | Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning |
| title_fullStr | Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning |
| title_full_unstemmed | Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning |
| title_short | Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning |
| title_sort | prediction of forelimb reach results from motor cortex activities based on calcium imaging and deep learning |
| topic | motor cortex two-photon imaging movement prediction deep learning convolutional neural network |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00088/full |
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