Co-exposure to BPA and DEHP enhances susceptibility of mammary tumors via up-regulating Esr1/HDAC6 pathway in female rats

Co-exposure to BPA and DEHP enhances susceptibility of mammary tumors via up-regulating Esr1/HDAC6 pathway in female rats

Breast cancer (BrCa) as one of the major malignancies threatening women's health worldwide occurs due to the genetic and environmental interactions. Epidemiological studies have suggested that exposure to endocrine disrupting chemicals (EDCs) can elevate the risk of breast cancer. Di-(2-ethylhe...

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Bibliographic Details
Main Authors: Xuan Zhang, Cheng Cheng, Guopei Zhang, Mingyang Xiao, Liuli Li, Shengwen Wu, Xiaobo Lu
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Mammary tumor
Di-(2-ethylhexyl)-phthalate (DEHP)
Bisphenol A (BPA)
Combined exposure
Esr1
HDAC6
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321005650

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