Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/23/11/3016 |
| _version_ | 1819071417481691136 |
|---|---|
| author | Fengming Lin Yan-Wen Bao Fu-Gen Wu |
| author_facet | Fengming Lin Yan-Wen Bao Fu-Gen Wu |
| author_sort | Fengming Lin |
| collection | DOAJ |
| description | Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds. |
| first_indexed | 2024-12-21T17:21:30Z |
| format | Article |
| id | doaj.art-5c56fb186b184588928e1ba76e0e4c9e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T17:21:30Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5c56fb186b184588928e1ba76e0e4c9e2022-12-21T18:56:09ZengMDPI AGMolecules1420-30492018-11-012311301610.3390/molecules23113016molecules23113016Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting MitochondriaFengming Lin0Yan-Wen Bao1Fu-Gen Wu2State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaMitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds.https://www.mdpi.com/1420-3049/23/11/3016nanomedicinecancer therapyPDTPTTsubcellular organelle-targeting |
| spellingShingle | Fengming Lin Yan-Wen Bao Fu-Gen Wu Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria Molecules nanomedicine cancer therapy PDT PTT subcellular organelle-targeting |
| title | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
| title_full | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
| title_fullStr | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
| title_full_unstemmed | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
| title_short | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
| title_sort | improving the phototherapeutic efficiencies of molecular and nanoscale materials by targeting mitochondria |
| topic | nanomedicine cancer therapy PDT PTT subcellular organelle-targeting |
| url | https://www.mdpi.com/1420-3049/23/11/3016 |
| work_keys_str_mv | AT fengminglin improvingthephototherapeuticefficienciesofmolecularandnanoscalematerialsbytargetingmitochondria AT yanwenbao improvingthephototherapeuticefficienciesofmolecularandnanoscalematerialsbytargetingmitochondria AT fugenwu improvingthephototherapeuticefficienciesofmolecularandnanoscalematerialsbytargetingmitochondria |