Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease
Among several neurodegenerative diseases, Huntington disease has posed a major threat across the world, particularly in the aged population. The disease is caused due to expansion of cytosine-adenine-guanine repeats which further triggers the formation of a mutant huntingtin protein responsible for...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622001177 |
| _version_ | 1818481411060924416 |
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| author | Pradeep Singh Garima Mishra Mulugeta Molla Yohannes Shumet Yimer Woretaw Sisay Yared Andargie Amien Ewunetie |
| author_facet | Pradeep Singh Garima Mishra Mulugeta Molla Yohannes Shumet Yimer Woretaw Sisay Yared Andargie Amien Ewunetie |
| author_sort | Pradeep Singh |
| collection | DOAJ |
| description | Among several neurodegenerative diseases, Huntington disease has posed a major threat across the world, particularly in the aged population. The disease is caused due to expansion of cytosine-adenine-guanine repeats which further triggers the formation of a mutant huntingtin protein responsible for neuronal death. Numerous pathophysiologic mechanisms have been implicated in Huntington’s disease. Striatum and cortex represent the most affected parts of the brain. Even though a wide range of medicines are available but they possess serious side effects. Therefore, the emergence of nutraceuticals derived from natural sources has received great attention in the pharmaceutical domain. Nutraceuticals are health-promoting supplements and enhance immunity in human beings. Currently, oxidative stress is the leading factor for chronic diseases that occur due to low intake of antioxidants. Herbal nutraceuticals are said to be enriched with a massive number of antioxidants. Therefore, this article throws light on various herbal nutraceuticals and their noteworthy effects on Huntington’s disease. |
| first_indexed | 2024-12-10T11:34:43Z |
| format | Article |
| id | doaj.art-5c56ff57293c4dcf83405c7679195510 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-10T11:34:43Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-5c56ff57293c4dcf83405c76791955102022-12-22T01:50:28ZengElsevierJournal of Functional Foods1756-46462022-05-0192105047Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s diseasePradeep Singh0Garima Mishra1Mulugeta Molla2Yohannes Shumet Yimer3Woretaw Sisay4Yared Andargie5Amien Ewunetie6Pharmaceutical Chemistry Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; Corresponding author.Pharmaceutical Chemistry Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaSocial Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaAmong several neurodegenerative diseases, Huntington disease has posed a major threat across the world, particularly in the aged population. The disease is caused due to expansion of cytosine-adenine-guanine repeats which further triggers the formation of a mutant huntingtin protein responsible for neuronal death. Numerous pathophysiologic mechanisms have been implicated in Huntington’s disease. Striatum and cortex represent the most affected parts of the brain. Even though a wide range of medicines are available but they possess serious side effects. Therefore, the emergence of nutraceuticals derived from natural sources has received great attention in the pharmaceutical domain. Nutraceuticals are health-promoting supplements and enhance immunity in human beings. Currently, oxidative stress is the leading factor for chronic diseases that occur due to low intake of antioxidants. Herbal nutraceuticals are said to be enriched with a massive number of antioxidants. Therefore, this article throws light on various herbal nutraceuticals and their noteworthy effects on Huntington’s disease.http://www.sciencedirect.com/science/article/pii/S1756464622001177Huntington's DiseaseMutant Huntingtin ProteinStriatumQuinolinic Acid3-Nitropropionic AcidAntioxidant |
| spellingShingle | Pradeep Singh Garima Mishra Mulugeta Molla Yohannes Shumet Yimer Woretaw Sisay Yared Andargie Amien Ewunetie Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease Journal of Functional Foods Huntington's Disease Mutant Huntingtin Protein Striatum Quinolinic Acid 3-Nitropropionic Acid Antioxidant |
| title | Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease |
| title_full | Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease |
| title_fullStr | Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease |
| title_full_unstemmed | Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease |
| title_short | Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease |
| title_sort | dietary and nutraceutical based therapeutic approaches to combat the pathogenesis of huntington s disease |
| topic | Huntington's Disease Mutant Huntingtin Protein Striatum Quinolinic Acid 3-Nitropropionic Acid Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622001177 |
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