Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma

Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma

<p>Abstract</p> <p>Background</p> <p>Germline mutations of the SDHD, SDHB and SDHC genes, encoding three of the four subunits of succinate dehydrogenase, are a major cause of hereditary paraganglioma and pheochromocytoma, and demonstrate that these genes are classic tum...

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Main Authors: Wong Nora, Ferrando Barbara, Pasini Barbara, Menko Fred H, Oomen Peter HN, Jansen Jeroen C, Weiss Marjan M, van Minderhout Ivonne, Bayley Jean-Pierre, Alpert Lesley C, Williams Rosie, Blair Edward, Devilee Peter, Taschner Peter EM
Format: Article
Language:English
Published: BMC 2006-01-01
Series:BMC Medical Genetics
Online Access:http://www.biomedcentral.com/1471-2350/7/1

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