Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalisation for respiratory diseases among children under 5 years old. The aim of this study was to analyse RSV seasonality in the five distinct regions of Brazil using time series analysis (wavelet and Fourier series) of the fo...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2016-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005005101&lng=en&tlng=en |
| _version_ | 1797715782534168576 |
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| author | André Ricardo Ribas Freitas Maria Rita Donalisio |
| author_facet | André Ricardo Ribas Freitas Maria Rita Donalisio |
| author_sort | André Ricardo Ribas Freitas |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) infection is the leading cause of hospitalisation for respiratory diseases among children under 5 years old. The aim of this study was to analyse RSV seasonality in the five distinct regions of Brazil using time series analysis (wavelet and Fourier series) of the following indicators: monthly positivity of the immunofluorescence reaction for RSV identified by virologic surveillance system, and rate of hospitalisations per bronchiolitis and pneumonia due to RSV in children under 5 years old (codes CID-10 J12.1, J20.5, J21.0 and J21.9). A total of 12,501 samples with 11.6% positivity for RSV (95% confidence interval 11 - 12.2), varying between 7.1 and 21.4% in the five Brazilian regions, was analysed. A strong trend for annual cycles with a stable stationary pattern in the five regions was identified through wavelet analysis of the indicators. The timing of RSV activity by Fourier analysis was similar between the two indicators analysed and showed regional differences. This study reinforces the importance of adjusting the immunisation period for high risk population with the monoclonal antibody palivizumab taking into account regional differences in seasonality of RSV. |
| first_indexed | 2024-03-12T08:11:54Z |
| format | Article |
| id | doaj.art-5c5ac93efa38456da8f2b2ff60b3ed38 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:54Z |
| publishDate | 2016-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-5c5ac93efa38456da8f2b2ff60b3ed382023-09-02T19:06:41ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602016-01-01010.1590/0074-02760150341S0074-02762016005005101Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populationsAndré Ricardo Ribas FreitasMaria Rita DonalisioRespiratory syncytial virus (RSV) infection is the leading cause of hospitalisation for respiratory diseases among children under 5 years old. The aim of this study was to analyse RSV seasonality in the five distinct regions of Brazil using time series analysis (wavelet and Fourier series) of the following indicators: monthly positivity of the immunofluorescence reaction for RSV identified by virologic surveillance system, and rate of hospitalisations per bronchiolitis and pneumonia due to RSV in children under 5 years old (codes CID-10 J12.1, J20.5, J21.0 and J21.9). A total of 12,501 samples with 11.6% positivity for RSV (95% confidence interval 11 - 12.2), varying between 7.1 and 21.4% in the five Brazilian regions, was analysed. A strong trend for annual cycles with a stable stationary pattern in the five regions was identified through wavelet analysis of the indicators. The timing of RSV activity by Fourier analysis was similar between the two indicators analysed and showed regional differences. This study reinforces the importance of adjusting the immunisation period for high risk population with the monoclonal antibody palivizumab taking into account regional differences in seasonality of RSV.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005005101&lng=en&tlng=enrespiratory syncytial virusseasonalitypalivizumabtime series analysis |
| spellingShingle | André Ricardo Ribas Freitas Maria Rita Donalisio Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations Memorias do Instituto Oswaldo Cruz respiratory syncytial virus seasonality palivizumab time series analysis |
| title | Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations |
| title_full | Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations |
| title_fullStr | Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations |
| title_full_unstemmed | Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations |
| title_short | Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations |
| title_sort | respiratory syncytial virus seasonality in brazil implications for the immunisation policy for at risk populations |
| topic | respiratory syncytial virus seasonality palivizumab time series analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005005101&lng=en&tlng=en |
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