Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence

Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence

Senescence is a phenomenon defined by alterations in cellular organelles and is the primary cause of aging and aging-related diseases. Recent studies have shown that oncogene-induced senescence is driven by activation of serine/threonine protein kinases (AKT1, AKT2 and AKT3). In this study, we evalu...

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Bibliographic Details
Main Authors: Myeong Uk Kuk, Haneur Lee, Eun Seon Song, Yun Haeng Lee, Ji Yun Park, Subin Jeong, Hyung Wook Kwon, Youngjoo Byun, Sang Chul Park, Joon Tae Park
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Experimental Gerontology
Subjects:
AKT
GDC0068
Senescence amelioration
Lysosome
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556523000128

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