The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients
Objectives: We aimed to compare the recall rate (RR) and the cancer detection rate (CDR) of combined full field digital mammography and digital breast tomosynthesis (FFDM + DBT) to those of full field digital mammography (FFDM) alone in breast cancer survivors. Methods: We enrolled 146 female breast...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X18301700 |
| _version_ | 1818524798070816768 |
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| author | Noha Mohamed Osman Enas Abdel Ghany Nivine Chalabi |
| author_facet | Noha Mohamed Osman Enas Abdel Ghany Nivine Chalabi |
| author_sort | Noha Mohamed Osman |
| collection | DOAJ |
| description | Objectives: We aimed to compare the recall rate (RR) and the cancer detection rate (CDR) of combined full field digital mammography and digital breast tomosynthesis (FFDM + DBT) to those of full field digital mammography (FFDM) alone in breast cancer survivors. Methods: We enrolled 146 female breast cancer survivors schedule. All patients underwent FFDM and DBT in the same setting. Results of FFDM alone were compared to those of FFDM + DBT regarding patients' RR and CDR.Sensitivity, specificity, accuracy, positive and negative predictive values were also calculated for FFDM alone and for FFDM + DBT in detecting breast cancer lesions. Results: Our results showed that FFDM + DBT decreased patients' RR by 3.4% and increased the CDR by 4.1%. Reduction in RR was evident in higher breast densities. FFDM mammography had 18 false negative lesions and 29 false positives. Sensitivity, specificity, accuracy, NPV and PPV in detecting breast lesions were: 84.2%, 53.1%, 64.0%, 86.7% and 48.9% for FFDM compared to 100%, 92.1%, 95.3%, 100% and 89.7% for FFDM + DBT. Conclusion: Combined FFDM + DBT in the post breast cancer surveillance regimen has shown to reduce the patients' RR and to increase the CDR. FFDM + DBT had higher diagnostic accuracy than FFDM alone. FFDM + DBT ought to be a standard combination in the breast cancer surveillance in treated patients. Keywords: Breast cancer, Full field digital mammography, Digital breast tomosynthesis, Recall rate, Cancer detection rate, Breast cancer surveillance |
| first_indexed | 2024-12-11T06:01:35Z |
| format | Article |
| id | doaj.art-5c5c148d34934aafbeb4c9dfa2067bc3 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-11T06:01:35Z |
| publishDate | 2018-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-5c5c148d34934aafbeb4c9dfa2067bc32022-12-22T01:18:27ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2018-12-0149411821186The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patientsNoha Mohamed Osman0Enas Abdel Ghany1Nivine Chalabi2Corresponding author at: 81 Mohy Eldeen Abdel Hameed, 8th District, Nasr City, Cairo, Egypt.; Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo, EgyptObjectives: We aimed to compare the recall rate (RR) and the cancer detection rate (CDR) of combined full field digital mammography and digital breast tomosynthesis (FFDM + DBT) to those of full field digital mammography (FFDM) alone in breast cancer survivors. Methods: We enrolled 146 female breast cancer survivors schedule. All patients underwent FFDM and DBT in the same setting. Results of FFDM alone were compared to those of FFDM + DBT regarding patients' RR and CDR.Sensitivity, specificity, accuracy, positive and negative predictive values were also calculated for FFDM alone and for FFDM + DBT in detecting breast cancer lesions. Results: Our results showed that FFDM + DBT decreased patients' RR by 3.4% and increased the CDR by 4.1%. Reduction in RR was evident in higher breast densities. FFDM mammography had 18 false negative lesions and 29 false positives. Sensitivity, specificity, accuracy, NPV and PPV in detecting breast lesions were: 84.2%, 53.1%, 64.0%, 86.7% and 48.9% for FFDM compared to 100%, 92.1%, 95.3%, 100% and 89.7% for FFDM + DBT. Conclusion: Combined FFDM + DBT in the post breast cancer surveillance regimen has shown to reduce the patients' RR and to increase the CDR. FFDM + DBT had higher diagnostic accuracy than FFDM alone. FFDM + DBT ought to be a standard combination in the breast cancer surveillance in treated patients. Keywords: Breast cancer, Full field digital mammography, Digital breast tomosynthesis, Recall rate, Cancer detection rate, Breast cancer surveillancehttp://www.sciencedirect.com/science/article/pii/S0378603X18301700 |
| spellingShingle | Noha Mohamed Osman Enas Abdel Ghany Nivine Chalabi The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients The Egyptian Journal of Radiology and Nuclear Medicine |
| title | The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients |
| title_full | The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients |
| title_fullStr | The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients |
| title_full_unstemmed | The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients |
| title_short | The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients |
| title_sort | added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X18301700 |
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