Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin

Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin

This article presents experimental evidence and computed molecular models of a potential interaction between receptor domain D5 of TrkB with the carboxyl-terminal domain of tetanus neurotoxin (Hc-TeNT). Computational simulations of a novel small cyclic oligopeptide are designed, synthesized, and tes...

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Bibliographic Details
Main Authors: Ana Candalija, Thomas Scior, Hans-Richard Rackwitz, Jordan E. Ruiz-Castelan, Ygnacio Martinez-Laguna, José Aguilera
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
clostridium neurotoxins
neurotrophin receptors
carboxyl-terminal domain of tetanus neurotoxin
brain-derived neurotrophic factor
Online Access:https://www.mdpi.com/1420-3049/26/13/3988

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