The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria

Malaria is a deadly infectious disease associated with fundamental changes in the composition of the memory B cell (MBC) compartment, most notably a large expansion of T-bet+ MBCs, termed atypical MBCs. However, we know little about the precursors of atypical MBCs and the conditions that drive their...

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Bibliographic Details
Main Authors: Abhijit A. Ambegaonkar, Satoshi Nagata, Susan K. Pierce, Haewon Sohn
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
atypical memory B cells
malaria
T-bet
B cell receptor signaling
TLR9
IFN-γ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00852/full

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