Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin

Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin

Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent therapeutic potential, their effectiveness in a wide range of tumors is limited by the development of resistance mechanisms. One of these mechanisms i...

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Bibliographic Details
Main Authors: Marta Mariniello, Raffaella Petruzzelli, Luca G. Wanderlingh, Raffaele La Montagna, Annamaria Carissimo, Francesca Pane, Angela Amoresano, Ekaterina Y. Ilyechova, Michael M. Galagudza, Federico Catalano, Roberta Crispino, Ludmila V. Puchkova, Diego L. Medina, Roman S. Polishchuk
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
cancer
cisplatin resistance
atp7b
copper transporters
synthetic lethality screening
fda-approved drugs
Online Access:https://www.mdpi.com/2072-6694/12/3/608

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