A gene mapping bottleneck in the translational route from zebrafish to human
Among a diversity of animal models of disease, the zebrafish is a promising model organism for enabling novel translational biomedical research. To fully achieve the latter, a key requirement is to match molecular readouts measured in zebrafish with information relevant to health and disease in huma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00470/full |
| _version_ | 1819260226069594112 |
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| author | Niek ede Klein Niek ede Klein Mark eIbberson Isaac eCrespo Sophie eRodius Francisco eAzuaje |
| author_facet | Niek ede Klein Niek ede Klein Mark eIbberson Isaac eCrespo Sophie eRodius Francisco eAzuaje |
| author_sort | Niek ede Klein |
| collection | DOAJ |
| description | Among a diversity of animal models of disease, the zebrafish is a promising model organism for enabling novel translational biomedical research. To fully achieve the latter, a key requirement is to match molecular readouts measured in zebrafish with information relevant to health and disease in humans. A fundamental step in this direction is to accurately map gene sequences from zebrafish to humans. Despite significant progress in genome annotation, this remains an intricate and time-consuming challenge. Here we discuss major obstacles that we had to overcome to systematically map genes from zebrafish to human. We identified important disparities, as well as partial agreements, between five public zebrafish-to-human homology resources. There is still a need for standardized, comprehensive genomic mappings between zebrafish and humans. Without this, efforts to use zebrafish as a powerful translational research tool will be stalled. |
| first_indexed | 2024-12-23T19:22:32Z |
| format | Article |
| id | doaj.art-5c5eac03764e4b389e77dcc6de9eca1e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-23T19:22:32Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-5c5eac03764e4b389e77dcc6de9eca1e2022-12-21T17:34:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-01-01510.3389/fgene.2014.00470126188A gene mapping bottleneck in the translational route from zebrafish to humanNiek ede Klein0Niek ede Klein1Mark eIbberson2Isaac eCrespo3Sophie eRodius4Francisco eAzuaje5Luxembourg Institute of HealthVrije UniversiteitSIB Swiss Institute of BioinformaticsSIB Swiss Institute of BioinformaticsLuxembourg Institute of HealthLuxembourg Institute of HealthAmong a diversity of animal models of disease, the zebrafish is a promising model organism for enabling novel translational biomedical research. To fully achieve the latter, a key requirement is to match molecular readouts measured in zebrafish with information relevant to health and disease in humans. A fundamental step in this direction is to accurately map gene sequences from zebrafish to humans. Despite significant progress in genome annotation, this remains an intricate and time-consuming challenge. Here we discuss major obstacles that we had to overcome to systematically map genes from zebrafish to human. We identified important disparities, as well as partial agreements, between five public zebrafish-to-human homology resources. There is still a need for standardized, comprehensive genomic mappings between zebrafish and humans. Without this, efforts to use zebrafish as a powerful translational research tool will be stalled.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00470/fullZebrafishTranslational researchzebrafish-to-human gene mappingorthology inferencegenome annotation. |
| spellingShingle | Niek ede Klein Niek ede Klein Mark eIbberson Isaac eCrespo Sophie eRodius Francisco eAzuaje A gene mapping bottleneck in the translational route from zebrafish to human Frontiers in Genetics Zebrafish Translational research zebrafish-to-human gene mapping orthology inference genome annotation. |
| title | A gene mapping bottleneck in the translational route from zebrafish to human |
| title_full | A gene mapping bottleneck in the translational route from zebrafish to human |
| title_fullStr | A gene mapping bottleneck in the translational route from zebrafish to human |
| title_full_unstemmed | A gene mapping bottleneck in the translational route from zebrafish to human |
| title_short | A gene mapping bottleneck in the translational route from zebrafish to human |
| title_sort | gene mapping bottleneck in the translational route from zebrafish to human |
| topic | Zebrafish Translational research zebrafish-to-human gene mapping orthology inference genome annotation. |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00470/full |
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