Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis
Oxidative stress is believed to play a critical role in atherosclerosis initiation and progression. In line with this, in a group of 1099 subjects, we determined eight single nucleotide polymorphisms (SNPs) related to oxidative stress (<i>PON1</i> c.575A>G, <i>MPO</i> c.−4...
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2020-09-01
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| author | Milena Racis Anna Stanisławska-Sachadyn Wojciech Sobiczewski Marcin Wirtwein Michał Krzemiński Natalia Krawczyńska Janusz Limon Andrzej Rynkiewicz Marcin Gruchała |
| author_facet | Milena Racis Anna Stanisławska-Sachadyn Wojciech Sobiczewski Marcin Wirtwein Michał Krzemiński Natalia Krawczyńska Janusz Limon Andrzej Rynkiewicz Marcin Gruchała |
| author_sort | Milena Racis |
| collection | DOAJ |
| description | Oxidative stress is believed to play a critical role in atherosclerosis initiation and progression. In line with this, in a group of 1099 subjects, we determined eight single nucleotide polymorphisms (SNPs) related to oxidative stress (<i>PON1</i> c.575A>G, <i>MPO</i> c.−463G>A, <i>SOD2</i> c.47T>C, <i>GCLM</i> c.−590C>T, <i>NOS3</i> c.894G>T, <i>NOS3</i> c.−786T>C, <i>CYBA</i> c.214C>T, and <i>CYBA</i> c.−932A>G) and assessed the extent of atherosclerosis in coronary arteries based on Gensini score. An increased risk of having a Gensini score in the higher half of the distribution was observed for the <i>PON1</i> c.575G allele (odds ratio (OR) = 1.27, 95% confidence interval (CI): 1.004–1.617, <i>p</i> = 0.046). Next, the genetic risk score (GRS) for the additive effect of the total number of pro-oxidative alleles was assessed. We noted an increase in the risk of having a Gensini score above the median with the maximum number of risk alleles (OR = 2.47, 95% CI: 1.19–5.23, <i>p</i> = 0.014). A univariate Spearman’s test revealed significant correlation between the total number of pro-oxidant alleles (GRS) and the Gensini score (ρ = 0.068, <i>p</i> = 0.03). In conclusion, the <i>PON1</i> c.575A>G variant and the high number of risk alleles (GRS) were independent risk factors for a high Gensini score. We suggest, however, that GRS might occur as a more valuable component in adding a predictive value to the genetic background of atherosclerosis. |
| first_indexed | 2024-03-10T16:14:29Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-10T16:14:29Z |
| publishDate | 2020-09-01 |
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| spelling | doaj.art-5c5ec7bbcd81436b854cd88a6e56d5672023-11-20T14:10:07ZengMDPI AGLife2075-17292020-09-0110921010.3390/life10090210Association of Genes Related to Oxidative Stress with the Extent of Coronary AtherosclerosisMilena Racis0Anna Stanisławska-Sachadyn1Wojciech Sobiczewski2Marcin Wirtwein3Michał Krzemiński4Natalia Krawczyńska5Janusz Limon6Andrzej Rynkiewicz7Marcin Gruchała8First Department of Cardiology, Medical University of Gdańsk, ul. Dębinki 7, 80-211 Gdańsk, PolandDepartment of Biology and Genetics, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, PolandFirst Department of Cardiology, Medical University of Gdańsk, ul. Dębinki 7, 80-211 Gdańsk, PolandDepartment of Pharmacology, Medical University of Gdańsk, ul. Dębinki 7, 80-211 Gdańsk, PolandDepartment of Probability and Biomathematics, Gdańsk University of Technology, ul. Narutowicza 11/12, 80-233 Gdańsk, PolandDepartment of Biology and Genetics, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, PolandDepartment of Biology and Genetics, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, PolandDepartment of Cardiology and Cardiosurgery, University of Warmia and Mazury in Olsztyn, Al. Warszawska 30, 10-082 Olsztyn, PolandFirst Department of Cardiology, Medical University of Gdańsk, ul. Dębinki 7, 80-211 Gdańsk, PolandOxidative stress is believed to play a critical role in atherosclerosis initiation and progression. In line with this, in a group of 1099 subjects, we determined eight single nucleotide polymorphisms (SNPs) related to oxidative stress (<i>PON1</i> c.575A>G, <i>MPO</i> c.−463G>A, <i>SOD2</i> c.47T>C, <i>GCLM</i> c.−590C>T, <i>NOS3</i> c.894G>T, <i>NOS3</i> c.−786T>C, <i>CYBA</i> c.214C>T, and <i>CYBA</i> c.−932A>G) and assessed the extent of atherosclerosis in coronary arteries based on Gensini score. An increased risk of having a Gensini score in the higher half of the distribution was observed for the <i>PON1</i> c.575G allele (odds ratio (OR) = 1.27, 95% confidence interval (CI): 1.004–1.617, <i>p</i> = 0.046). Next, the genetic risk score (GRS) for the additive effect of the total number of pro-oxidative alleles was assessed. We noted an increase in the risk of having a Gensini score above the median with the maximum number of risk alleles (OR = 2.47, 95% CI: 1.19–5.23, <i>p</i> = 0.014). A univariate Spearman’s test revealed significant correlation between the total number of pro-oxidant alleles (GRS) and the Gensini score (ρ = 0.068, <i>p</i> = 0.03). In conclusion, the <i>PON1</i> c.575A>G variant and the high number of risk alleles (GRS) were independent risk factors for a high Gensini score. We suggest, however, that GRS might occur as a more valuable component in adding a predictive value to the genetic background of atherosclerosis.https://www.mdpi.com/2075-1729/10/9/210oxidative stresspolymorphismSNPatherosclerosisCADcardiovascular disease |
| spellingShingle | Milena Racis Anna Stanisławska-Sachadyn Wojciech Sobiczewski Marcin Wirtwein Michał Krzemiński Natalia Krawczyńska Janusz Limon Andrzej Rynkiewicz Marcin Gruchała Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis Life oxidative stress polymorphism SNP atherosclerosis CAD cardiovascular disease |
| title | Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis |
| title_full | Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis |
| title_fullStr | Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis |
| title_full_unstemmed | Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis |
| title_short | Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis |
| title_sort | association of genes related to oxidative stress with the extent of coronary atherosclerosis |
| topic | oxidative stress polymorphism SNP atherosclerosis CAD cardiovascular disease |
| url | https://www.mdpi.com/2075-1729/10/9/210 |
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