PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice
Chemotherapy-induced cachexia has been a significant challenge to the successful treatment of cancer patients. Chemotherapy leads to loss of muscle, loss of appetite, and excessive weight loss, which makes these necessary treatments intolerable for most patients. Therefore, it is necessary to allevi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322000602 |
| _version_ | 1818126423357915136 |
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| author | Guen Tae Kim Eun Young Kim Su-Hyun Shin Hyowon Lee Se Hee Lee Kaapjoo Park Ki-Young Sohn Sun Young Yoon Jae Wha Kim |
| author_facet | Guen Tae Kim Eun Young Kim Su-Hyun Shin Hyowon Lee Se Hee Lee Kaapjoo Park Ki-Young Sohn Sun Young Yoon Jae Wha Kim |
| author_sort | Guen Tae Kim |
| collection | DOAJ |
| description | Chemotherapy-induced cachexia has been a significant challenge to the successful treatment of cancer patients. Chemotherapy leads to loss of muscle, loss of appetite, and excessive weight loss, which makes these necessary treatments intolerable for most patients. Therefore, it is necessary to alleviate cachexia to successfully treat cancer patients.In this study, tumor-implanted mouse models administered cisplatin showed rapid weight loss and reduced feeding rate by the second week of treatment, and 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) effectively alleviated cisplatin-induced cachexia. In mice treated with cisplatin on a sacrificial day after 6 weeks, the weight of the two major leg muscles (quadriceps femoris and gastrocnemius) were reduced by up to 70%, but this muscle reduction was successfully prevented in the PLAG co-treatment group. The distribution and size of muscle fibers that appear in small units in cisplatin-treated mice were restored to normal levels by PLAG co-treatment. Furthermore, myostatin expression levels were upregulated by cisplatin, whereas myostatin decreased to normal levels with muscle recovery in the PLAG co-treated group. Tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), which are commonly expressed in cachexia, were significantly increased in cisplatin-treated mice but were reduced to normal levels in PLAG co-treated mice. Glucose absorption, an indicator of muscle tissue activity, decreased with cisplatin treatment and recovered to normal levels with PLAG co-treatment. Overall, PLAG effectively alleviated cisplatin-induced cachexia symptoms and reduced tumor growth in tumor-implanted mice.These findings suggest PLAG may be a promising drug to alleviate cachexia in cancer patients receiving chemotherapy. |
| first_indexed | 2024-12-11T07:01:13Z |
| format | Article |
| id | doaj.art-5c609c97aeaa4dee8458d031669b2d15 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-11T07:01:13Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-5c609c97aeaa4dee8458d031669b2d152022-12-22T01:16:36ZengElsevierTranslational Oncology1936-52332022-06-0120101398PLAG alleviates cisplatin-induced cachexia in lung cancer implanted miceGuen Tae Kim0Eun Young Kim1Su-Hyun Shin2Hyowon Lee3Se Hee Lee4Kaapjoo Park5Ki-Young Sohn6Sun Young Yoon7Jae Wha Kim8Enzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South KoreaEnzychem Lifesciences, 10F aT Center 27 Gangnam-daero, Seoul, South Korea; Corresponding author at: Biology R&D, Enzychem Lifesciences, Seoul, South Korea.Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Kwahak-ro, Daejeon, South Korea; Corresponding author at: Cell Factory Research Center, Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.Chemotherapy-induced cachexia has been a significant challenge to the successful treatment of cancer patients. Chemotherapy leads to loss of muscle, loss of appetite, and excessive weight loss, which makes these necessary treatments intolerable for most patients. Therefore, it is necessary to alleviate cachexia to successfully treat cancer patients.In this study, tumor-implanted mouse models administered cisplatin showed rapid weight loss and reduced feeding rate by the second week of treatment, and 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) effectively alleviated cisplatin-induced cachexia. In mice treated with cisplatin on a sacrificial day after 6 weeks, the weight of the two major leg muscles (quadriceps femoris and gastrocnemius) were reduced by up to 70%, but this muscle reduction was successfully prevented in the PLAG co-treatment group. The distribution and size of muscle fibers that appear in small units in cisplatin-treated mice were restored to normal levels by PLAG co-treatment. Furthermore, myostatin expression levels were upregulated by cisplatin, whereas myostatin decreased to normal levels with muscle recovery in the PLAG co-treated group. Tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), which are commonly expressed in cachexia, were significantly increased in cisplatin-treated mice but were reduced to normal levels in PLAG co-treated mice. Glucose absorption, an indicator of muscle tissue activity, decreased with cisplatin treatment and recovered to normal levels with PLAG co-treatment. Overall, PLAG effectively alleviated cisplatin-induced cachexia symptoms and reduced tumor growth in tumor-implanted mice.These findings suggest PLAG may be a promising drug to alleviate cachexia in cancer patients receiving chemotherapy.http://www.sciencedirect.com/science/article/pii/S1936523322000602PLAGCisplatinCachexiaMuscle atrophyLung carcinoma |
| spellingShingle | Guen Tae Kim Eun Young Kim Su-Hyun Shin Hyowon Lee Se Hee Lee Kaapjoo Park Ki-Young Sohn Sun Young Yoon Jae Wha Kim PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice Translational Oncology PLAG Cisplatin Cachexia Muscle atrophy Lung carcinoma |
| title | PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice |
| title_full | PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice |
| title_fullStr | PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice |
| title_full_unstemmed | PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice |
| title_short | PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice |
| title_sort | plag alleviates cisplatin induced cachexia in lung cancer implanted mice |
| topic | PLAG Cisplatin Cachexia Muscle atrophy Lung carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322000602 |
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