Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions
Infectious diseases caused by bacteria have led to a great threat to public health. With the significant advances in nanotechnology in recent decades, nanomaterials have emerged as a powerful tool to boost antibacterial performance due to either intrinsic bactericidal properties or by enhancing the...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/5/685 |
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| author | Chengang Ni Yuening Zhong Weixi Wu Yaping Song Pooyan Makvandi Chengzhong Yu Hao Song |
| author_facet | Chengang Ni Yuening Zhong Weixi Wu Yaping Song Pooyan Makvandi Chengzhong Yu Hao Song |
| author_sort | Chengang Ni |
| collection | DOAJ |
| description | Infectious diseases caused by bacteria have led to a great threat to public health. With the significant advances in nanotechnology in recent decades, nanomaterials have emerged as a powerful tool to boost antibacterial performance due to either intrinsic bactericidal properties or by enhancing the delivery efficiency of antibiotics for effective pathogen killing. Vancomycin, as one of the most widely employed antimicrobial peptides, has a potent bactericidal activity, but at the same time shows a limited bioavailability. Silver nanoparticles have also been extensively explored and were found to have a well-recognized antibacterial activity and limited resistance potential; however, how to prevent nanosized Ag particles from aggregation in biological conditions is challenging. In this study, we aimed to combine the advantages of both vancomycin and nano-Ag for enhanced bacterial killing, where both antibacterial agents were successfully loaded onto a silica nanoparticle with a pollen-like morphology. The morphology of nano-Ag-decorated silica nanopollens was characterized using transmission electron microscopy and elemental mapping through energy dispersive spectroscopy. Silver nanoparticles with a size of 10–25 nm were observed as well-distributed on the surface of silica nanoparticles of around 200 nm. The unique design of a spiky morphology of silica nano-carriers promoted the adhesion of nanoparticles towards bacterial surfaces to promote localized drug release for bacterial killing, where the bacterial damage was visualized through scanning electron microscopy. Enhanced bactericidal activity was demonstrated through this co-delivery of vancomycin and nano-Ag, decreasing the minimum inhibition concentration (MIC) towards <i>E. coli</i> and <i>S. epidermidis</i> down to 15 and 10 µg/mL. This study provides an efficient antimicrobial nano-strategy to address potential bacterial infections. |
| first_indexed | 2024-03-10T03:27:16Z |
| format | Article |
| id | doaj.art-5c628782761a4d889c430b71bb791aed |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T03:27:16Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5c628782761a4d889c430b71bb791aed2023-11-23T09:49:40ZengMDPI AGAntibiotics2079-63822022-05-0111568510.3390/antibiotics11050685Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial FunctionsChengang Ni0Yuening Zhong1Weixi Wu2Yaping Song3Pooyan Makvandi4Chengzhong Yu5Hao Song6Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, AustraliaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, AustraliaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, AustraliaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, AustraliaCenter for Materials Interfaces, Istituto Italiano di Tecnologia, Pontedera, 56025 Pisa, ItalyAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, AustraliaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, AustraliaInfectious diseases caused by bacteria have led to a great threat to public health. With the significant advances in nanotechnology in recent decades, nanomaterials have emerged as a powerful tool to boost antibacterial performance due to either intrinsic bactericidal properties or by enhancing the delivery efficiency of antibiotics for effective pathogen killing. Vancomycin, as one of the most widely employed antimicrobial peptides, has a potent bactericidal activity, but at the same time shows a limited bioavailability. Silver nanoparticles have also been extensively explored and were found to have a well-recognized antibacterial activity and limited resistance potential; however, how to prevent nanosized Ag particles from aggregation in biological conditions is challenging. In this study, we aimed to combine the advantages of both vancomycin and nano-Ag for enhanced bacterial killing, where both antibacterial agents were successfully loaded onto a silica nanoparticle with a pollen-like morphology. The morphology of nano-Ag-decorated silica nanopollens was characterized using transmission electron microscopy and elemental mapping through energy dispersive spectroscopy. Silver nanoparticles with a size of 10–25 nm were observed as well-distributed on the surface of silica nanoparticles of around 200 nm. The unique design of a spiky morphology of silica nano-carriers promoted the adhesion of nanoparticles towards bacterial surfaces to promote localized drug release for bacterial killing, where the bacterial damage was visualized through scanning electron microscopy. Enhanced bactericidal activity was demonstrated through this co-delivery of vancomycin and nano-Ag, decreasing the minimum inhibition concentration (MIC) towards <i>E. coli</i> and <i>S. epidermidis</i> down to 15 and 10 µg/mL. This study provides an efficient antimicrobial nano-strategy to address potential bacterial infections.https://www.mdpi.com/2079-6382/11/5/685nanomaterialsantibacterialsilica nanoparticlessilver nanoparticlesvancomycindrug delivery |
| spellingShingle | Chengang Ni Yuening Zhong Weixi Wu Yaping Song Pooyan Makvandi Chengzhong Yu Hao Song Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions Antibiotics nanomaterials antibacterial silica nanoparticles silver nanoparticles vancomycin drug delivery |
| title | Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions |
| title_full | Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions |
| title_fullStr | Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions |
| title_full_unstemmed | Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions |
| title_short | Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions |
| title_sort | co delivery of nano silver and vancomycin via silica nanopollens for enhanced antibacterial functions |
| topic | nanomaterials antibacterial silica nanoparticles silver nanoparticles vancomycin drug delivery |
| url | https://www.mdpi.com/2079-6382/11/5/685 |
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