The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait?
<i>Cutibacterium acnes</i> (<i>C. acnes</i>, formerly <i>Propionibacterium acnes</i>) is considered to be a non-pathogenic resident of the human skin, as well as mucosal surfaces. However, it also has been demonstrated that <i>C. acnes</i> plays a path...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/8/1649 |
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| author | Raisa Kraaijvanger Marcel Veltkamp |
| author_facet | Raisa Kraaijvanger Marcel Veltkamp |
| author_sort | Raisa Kraaijvanger |
| collection | DOAJ |
| description | <i>Cutibacterium acnes</i> (<i>C. acnes</i>, formerly <i>Propionibacterium acnes</i>) is considered to be a non-pathogenic resident of the human skin, as well as mucosal surfaces. However, it also has been demonstrated that <i>C. acnes</i> plays a pathogenic role in diseases such as acne vulgaris or implant infections after orthopedic surgery. Besides a role in infectious disease, this bacterium also seems to harbor immunomodulatory effects demonstrated by studies using <i>C. acnes</i> to enhance anti-tumor activity in various cancers or vaccination response. Sarcoidosis is a systemic inflammatory disorder of unknown causes. Cultures of <i>C. acnes</i> in biopsy samples of sarcoidosis patients, its presence in BAL fluid, tissue samples as well as antibodies against this bacterium found in serum of patients with sarcoidosis suggest an etiological role in this disease. In this review we address the antigenic as well as immunomodulatory potential of <i>C. acnes</i> with a focus on sarcoidosis. Furthermore, a potential role for antibiotic treatment in patients with sarcoidosis will be explored. |
| first_indexed | 2024-03-09T12:53:50Z |
| format | Article |
| id | doaj.art-5c62ed824ad9423f9ab379b1be7b4d70 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T12:53:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-5c62ed824ad9423f9ab379b1be7b4d702023-11-30T22:02:24ZengMDPI AGMicroorganisms2076-26072022-08-01108164910.3390/microorganisms10081649The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait?Raisa Kraaijvanger0Marcel Veltkamp1Interstitial Lung Diseases Centre of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The NetherlandsInterstitial Lung Diseases Centre of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands<i>Cutibacterium acnes</i> (<i>C. acnes</i>, formerly <i>Propionibacterium acnes</i>) is considered to be a non-pathogenic resident of the human skin, as well as mucosal surfaces. However, it also has been demonstrated that <i>C. acnes</i> plays a pathogenic role in diseases such as acne vulgaris or implant infections after orthopedic surgery. Besides a role in infectious disease, this bacterium also seems to harbor immunomodulatory effects demonstrated by studies using <i>C. acnes</i> to enhance anti-tumor activity in various cancers or vaccination response. Sarcoidosis is a systemic inflammatory disorder of unknown causes. Cultures of <i>C. acnes</i> in biopsy samples of sarcoidosis patients, its presence in BAL fluid, tissue samples as well as antibodies against this bacterium found in serum of patients with sarcoidosis suggest an etiological role in this disease. In this review we address the antigenic as well as immunomodulatory potential of <i>C. acnes</i> with a focus on sarcoidosis. Furthermore, a potential role for antibiotic treatment in patients with sarcoidosis will be explored.https://www.mdpi.com/2076-2607/10/8/1649<i>Cutibacterium acnes</i>immune modulationsarcoidosis |
| spellingShingle | Raisa Kraaijvanger Marcel Veltkamp The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait? Microorganisms <i>Cutibacterium acnes</i> immune modulation sarcoidosis |
| title | The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait? |
| title_full | The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait? |
| title_fullStr | The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait? |
| title_full_unstemmed | The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait? |
| title_short | The Role of <i>Cutibacterium acnes</i> in Sarcoidosis: From Antigen to Treatable Trait? |
| title_sort | role of i cutibacterium acnes i in sarcoidosis from antigen to treatable trait |
| topic | <i>Cutibacterium acnes</i> immune modulation sarcoidosis |
| url | https://www.mdpi.com/2076-2607/10/8/1649 |
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