The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases
BACKGROUND, OBJECTIVES The antibody titer of vaccine-preventable disease in 70 patients who underwent chemotherapy or haemopoietic stem cell transplantation (HSCT) was assessed in order to evaluate the seroprotection after treatment and the feasibility and the efficacy of a policy of revaccinatio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mattioli1885
2020-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/4100 |
| _version_ | 1819281452750077952 |
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| author | Chiara Garonzi Rita Balter Gloria Tridello Anna Pegoraro Manuela Pegoraro Monia Pacenti Novella Scattolo Simone Cesaro |
| author_facet | Chiara Garonzi Rita Balter Gloria Tridello Anna Pegoraro Manuela Pegoraro Monia Pacenti Novella Scattolo Simone Cesaro |
| author_sort | Chiara Garonzi |
| collection | DOAJ |
| description | BACKGROUND, OBJECTIVES
The antibody titer of vaccine-preventable disease in 70 patients who underwent chemotherapy or haemopoietic stem cell transplantation (HSCT) was assessed in order to evaluate the seroprotection after treatment and the feasibility and the efficacy of a policy of revaccination.
METHODS
Serum antibody titers of 70 patients for hepatitis B (HBV), Rubella, Varicella-zoster (VZV), Measles, Mumps, Polio viruses, Clostridium tetani (C. tetani) and Streptococcus pneumoniae (S. Pneumoniae) were analysed.
RESULTS
After chemotherapy, a lack of protective antibody titers against HBV, Rubella, VZV, Measles, Mumps, Polio viruses, C. tetani and S. Pneumoniae were found in 53%, 45%, 46%, 46%, 43%, 21-26%, 88% and 55% of patients, respectively. In patients who were tested both before and after chemotherapy, the loss of immunity was respectively 39%, 43%, 38%, 42%, 32%, 33%, and 80%. A low number of B-lymphocytes was associated with the loss of immunity against Measles (p=0.04) whereas a high number of CD8+ T-lymphocytes was associated with the loss of immunity against VZV (p=0.03). A single booster of vaccine dose resulted in a seroprotection for HBV, Rubella, VZV, Measles, Mumps, Polio viruses, C. tetani and S. Pneumoniae in 67%, 83%, 80%, 67%, 33%, 100%, 88% and 67% of patients, respectively.
After HSCT, the rates of lack and loss of vaccine immunity differ by the infectious disease considered.
CONCLUSIONS
We confirm that seroprotection for vaccine-preventable disease is affected by treatment for pediatric malignancy. A single booster dose of vaccine might be a practical way to restore vaccine immunity in patients after chemotherapy. |
| first_indexed | 2024-12-24T00:59:55Z |
| format | Article |
| id | doaj.art-5c638ff6ce6e4608949d9e23f6613b7b |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-24T00:59:55Z |
| publishDate | 2020-02-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-5c638ff6ce6e4608949d9e23f6613b7b2022-12-21T17:23:24ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062020-02-0112110.4084/mjhid.2020.014The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseasesChiara Garonzi0Rita Balter1Gloria Tridello2Anna Pegoraro3Manuela Pegoraro4Monia Pacenti5Novella Scattolo6Simone Cesaro Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata VeronaPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, ItalyPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, ItalyPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, ItalyMicrobiology and Virology Unit, Azienda Ospedaliera Universitaria Integrata Verona, ItalyMicrobiology and Virology Unit, Padova University Hospital, Padova, ItalyOspedale di San Bonifacio, Azienda AULSS 9 Scaligera, Verona, ItalyBACKGROUND, OBJECTIVES The antibody titer of vaccine-preventable disease in 70 patients who underwent chemotherapy or haemopoietic stem cell transplantation (HSCT) was assessed in order to evaluate the seroprotection after treatment and the feasibility and the efficacy of a policy of revaccination. METHODS Serum antibody titers of 70 patients for hepatitis B (HBV), Rubella, Varicella-zoster (VZV), Measles, Mumps, Polio viruses, Clostridium tetani (C. tetani) and Streptococcus pneumoniae (S. Pneumoniae) were analysed. RESULTS After chemotherapy, a lack of protective antibody titers against HBV, Rubella, VZV, Measles, Mumps, Polio viruses, C. tetani and S. Pneumoniae were found in 53%, 45%, 46%, 46%, 43%, 21-26%, 88% and 55% of patients, respectively. In patients who were tested both before and after chemotherapy, the loss of immunity was respectively 39%, 43%, 38%, 42%, 32%, 33%, and 80%. A low number of B-lymphocytes was associated with the loss of immunity against Measles (p=0.04) whereas a high number of CD8+ T-lymphocytes was associated with the loss of immunity against VZV (p=0.03). A single booster of vaccine dose resulted in a seroprotection for HBV, Rubella, VZV, Measles, Mumps, Polio viruses, C. tetani and S. Pneumoniae in 67%, 83%, 80%, 67%, 33%, 100%, 88% and 67% of patients, respectively. After HSCT, the rates of lack and loss of vaccine immunity differ by the infectious disease considered. CONCLUSIONS We confirm that seroprotection for vaccine-preventable disease is affected by treatment for pediatric malignancy. A single booster dose of vaccine might be a practical way to restore vaccine immunity in patients after chemotherapy.http://www.mjhid.org/index.php/mjhid/article/view/4100vaccinationpediatric malignancychemotherapyhematopoietic stem cell transplantation |
| spellingShingle | Chiara Garonzi Rita Balter Gloria Tridello Anna Pegoraro Manuela Pegoraro Monia Pacenti Novella Scattolo Simone Cesaro The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases Mediterranean Journal of Hematology and Infectious Diseases vaccination pediatric malignancy chemotherapy hematopoietic stem cell transplantation |
| title | The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases |
| title_full | The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases |
| title_fullStr | The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases |
| title_full_unstemmed | The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases |
| title_short | The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases |
| title_sort | impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine preventable diseases |
| topic | vaccination pediatric malignancy chemotherapy hematopoietic stem cell transplantation |
| url | http://www.mjhid.org/index.php/mjhid/article/view/4100 |
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