FARNESYL DIPHOSPHATE SYNTHASE (FDRS) AND GERANYLGERANYL DIPHOSPHATE SYNTHASE (GGSP1) GENE POLYMORPHISMS AND EFFICIENCY OF THERAPY WITH BISPHOSPHONATES IN RUSSIAN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A PILOT STUDY

FARNESYL DIPHOSPHATE SYNTHASE (FDRS) AND GERANYLGERANYL DIPHOSPHATE SYNTHASE (GGSP1) GENE POLYMORPHISMS AND EFFICIENCY OF THERAPY WITH BISPHOSPHONATES IN RUSSIAN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A PILOT STUDY

Genetic factors that are an important hereditary component determining a predisposition to osteoporosis (OP) are 60–80% responsible for bone mineral density (BMD). Some polymorphic genes have been previously shown to affect the efficiency of performed anti-osteoporotic therapy.Objective: to study th...

Full description

Bibliographic Details
Main Authors:	M. Yu. Krylov, O. A. Nikitinskaya, E. Yu. Samarkina, N. V. Demin, N. V. Toroptsova
Format:	Article
Language:	Russian
Published:	IMA PRESS LLC 2016-03-01
Series:	Научно-практическая ревматология
Subjects:	therapeutic efficiency polymorphisms osteoporosis bisphosphonates pharmacogenetics
Online Access:	https://rsp.mediar-press.net/rsp/article/view/2169

Similar Items

Search for genetic markers determining the efficiency of therapy with bisphosphonates in Russian women with postmenopausal osteoporosis: A pilot study
by: M. Yu. Krylov, et al.
Published: (2016-10-01)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
by: Heloisa B Gabriel, et al.
Published: (2018-08-01)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2002)

Synthesis of isoprenoid bisphosphonate ethers through C–P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase
by: Xiang Zhou, et al.
Published: (2014-07-01)

Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia
by: Ana Paula R. Gadelha, et al.
Published: (2020-04-01)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2005)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
by: Evdokimov, A, et al.
Published: (2006)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2007)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
by: Dunford, J, et al.
Published: (2006)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
by: Xia, Z, et al.
Published: (2007)

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
by: Hee Yeon Kim, et al.
Published: (2018-10-01)

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection
by: Melissa A. Sleda, et al.
Published: (2022-10-01)

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
by: Staci L. Haney, et al.
Published: (2017-05-01)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
by: Kavanagh, K, et al.
Published: (2005)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2006)

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target
by: Molly E. Muehlebach, et al.
Published: (2023-01-01)

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma
by: Staci L. Haney, et al.
Published: (2022-02-01)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
by: Ebetino, F, et al.
Published: (2002)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
by: Ebetino, F, et al.
Published: (2002)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
by: Kavanagh, K, et al.
Published: (2006)

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
by: Daoyong Gong, et al.
Published: (2022-10-01)

Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells
by: Asami Oike, et al.
Published: (2022-12-01)

Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
by: Johan Ericsson, et al.
Published: (1998-09-01)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
by: Jaeok Park, et al.
Published: (2021-01-01)

Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes
by: Dongrui Zhang, et al.
Published: (2023-03-01)

Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-<i>Trypanosomatidae</i> Drug Discovery
by: Boniface Pone Kamdem, et al.
Published: (2023-08-01)

Characterization of the Geranylgeranyl Diphosphate Synthase Gene in Acyrthosiphon pisum (Hemiptera: Aphididae) and Its Association With Carotenoid Biosynthesis
by: Bi-Yue Ding, et al.
Published: (2019-11-01)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
by: Xia, Z, et al.
Published: (2006)

Functional effects of the p.Asp188Tyr mutation in the Geranylgeranyl Diphosphate Synthase (GGPS1) gene associated with bisphosphonate-related atypical femoral fractures
by: Roca-Ayats, N, et al.
Published: (2017)

Biosynthesis of α-Bisabolol by Farnesyl Diphosphate Synthase and α-Bisabolol Synthase and Their Related Transcription Factors in <i>Matricaria recutita</i> L.
by: Yuling Tai, et al.
Published: (2023-01-01)

Molecular cloning and characterization of farnesyl diphosphate synthase from Rosa rugosa Thunb associated with salinity stress
by: Guo Wei, et al.
Published: (2024-02-01)

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z‑Farnesyl Diphosphate Synthase
by: Yueh-Te Chan, et al.
Published: (2017-03-01)

Identification of a novel class of ω,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis
by: Rakesh K. Dhiman, et al.
Published: (2004-06-01)

Functional verification and characterization of a type-III geranylgeranyl diphosphate synthase gene from Sporobolomyces pararoseus NGR
by: Jianyu Yan, et al.
Published: (2022-11-01)

Biosynthesis of Taxadiene in Saccharomyces cerevisiae : selection of geranylgeranyl diphosphate synthase directed by a computer-aided docking strategy.
by: Ming-Zhu Ding, et al.
Published: (2014-01-01)

New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
by: L. O. Metelytsia, et al.
Published: (2019-05-01)

A Small Subunit of Geranylgeranyl Diphosphate Synthase Functions as an Active Regulator of Carotenoid Synthesis in <i>Nicotiana tabacum</i>
by: Chen Dong, et al.
Published: (2023-01-01)

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
by: Tingting Jin, et al.
Published: (2022-08-01)

Genome-wide characterization and expression analysis of geranylgeranyl diphosphate synthase genes in cotton (Gossypium spp.) in plant development and abiotic stresses
by: Faiza Ali, et al.
Published: (2020-08-01)