The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis
Exosomes are lipid membrane bilayer-encapsulated vesicles secreted by cells into the extracellular space. They carry abundant inclusions (such as nucleic acids, proteins, and lipids) that play pivotal roles in intercellular communication. Tumor stem cells are capable of self-renewal and are crucial...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.836548/full |
| _version_ | 1831767335595147264 |
|---|---|
| author | Kun Liu Xin Gao Baoqiang Kang Yunpeng Liu Dingding Wang Yi Wang |
| author_facet | Kun Liu Xin Gao Baoqiang Kang Yunpeng Liu Dingding Wang Yi Wang |
| author_sort | Kun Liu |
| collection | DOAJ |
| description | Exosomes are lipid membrane bilayer-encapsulated vesicles secreted by cells into the extracellular space. They carry abundant inclusions (such as nucleic acids, proteins, and lipids) that play pivotal roles in intercellular communication. Tumor stem cells are capable of self-renewal and are crucial for survival, proliferation, drug resistance, metastasis, and recurrence of tumors. The miRNAs (microRNAs) in exosomes have various functions, such as participating in inflammatory response, cell migration, proliferation, apoptosis, autophagy, and epithelial-mesenchymal transition. Tumor stem cells secrete exosomes that act as important messengers involved in various tumor processes and several studies provide increasing evidence supporting the importance of these exosomes in tumor recurrence and metastasis. This review primarily focuses on the production and secretion of exosomes from tumors and tumor stem cells and their effects on cancer progression. Cancer stem cancer derived exosome play an important massager in the tumor microenvironment. It also emphasizes on the study of tumor stem cell exosomes in the light of cancer metastasis and recurrence aiming to provide valuable insights and novel perspectives, which could be beneficial for developing effective diagnostic and treatment strategies. |
| first_indexed | 2024-12-22T06:40:06Z |
| format | Article |
| id | doaj.art-5c65ca79d01c4334889ad27f4c99e387 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T06:40:06Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5c65ca79d01c4334889ad27f4c99e3872022-12-21T18:35:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.836548836548The Role of Tumor Stem Cell Exosomes in Cancer Invasion and MetastasisKun Liu0Xin Gao1Baoqiang Kang2Yunpeng Liu3Dingding Wang4Yi Wang5Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, ChangChun, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, ChangChun, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, ChangChun, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, Changchun, ChinaSchool of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, ChangChun, ChinaExosomes are lipid membrane bilayer-encapsulated vesicles secreted by cells into the extracellular space. They carry abundant inclusions (such as nucleic acids, proteins, and lipids) that play pivotal roles in intercellular communication. Tumor stem cells are capable of self-renewal and are crucial for survival, proliferation, drug resistance, metastasis, and recurrence of tumors. The miRNAs (microRNAs) in exosomes have various functions, such as participating in inflammatory response, cell migration, proliferation, apoptosis, autophagy, and epithelial-mesenchymal transition. Tumor stem cells secrete exosomes that act as important messengers involved in various tumor processes and several studies provide increasing evidence supporting the importance of these exosomes in tumor recurrence and metastasis. This review primarily focuses on the production and secretion of exosomes from tumors and tumor stem cells and their effects on cancer progression. Cancer stem cancer derived exosome play an important massager in the tumor microenvironment. It also emphasizes on the study of tumor stem cell exosomes in the light of cancer metastasis and recurrence aiming to provide valuable insights and novel perspectives, which could be beneficial for developing effective diagnostic and treatment strategies.https://www.frontiersin.org/articles/10.3389/fonc.2022.836548/fullcancer stem cellsexosomesmetastasistumortumor microenvironment |
| spellingShingle | Kun Liu Xin Gao Baoqiang Kang Yunpeng Liu Dingding Wang Yi Wang The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis Frontiers in Oncology cancer stem cells exosomes metastasis tumor tumor microenvironment |
| title | The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis |
| title_full | The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis |
| title_fullStr | The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis |
| title_full_unstemmed | The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis |
| title_short | The Role of Tumor Stem Cell Exosomes in Cancer Invasion and Metastasis |
| title_sort | role of tumor stem cell exosomes in cancer invasion and metastasis |
| topic | cancer stem cells exosomes metastasis tumor tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.836548/full |
| work_keys_str_mv | AT kunliu theroleoftumorstemcellexosomesincancerinvasionandmetastasis AT xingao theroleoftumorstemcellexosomesincancerinvasionandmetastasis AT baoqiangkang theroleoftumorstemcellexosomesincancerinvasionandmetastasis AT yunpengliu theroleoftumorstemcellexosomesincancerinvasionandmetastasis AT dingdingwang theroleoftumorstemcellexosomesincancerinvasionandmetastasis AT yiwang theroleoftumorstemcellexosomesincancerinvasionandmetastasis AT kunliu roleoftumorstemcellexosomesincancerinvasionandmetastasis AT xingao roleoftumorstemcellexosomesincancerinvasionandmetastasis AT baoqiangkang roleoftumorstemcellexosomesincancerinvasionandmetastasis AT yunpengliu roleoftumorstemcellexosomesincancerinvasionandmetastasis AT dingdingwang roleoftumorstemcellexosomesincancerinvasionandmetastasis AT yiwang roleoftumorstemcellexosomesincancerinvasionandmetastasis |