Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department
<i>Background and Objectives</i>: In order to accelerate the risk stratification of patients referred to the Emergency Department (ED) with interstitial pneumonia, it could be useful to provide new and effective laboratory tests for use. The aim of our study was to evaluate the prognosti...
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MDPI AG
2022-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/12/1852 |
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| author | Ilaria Dafne Papasidero Gabriele Valli Dario Marin Alberto Del Sasso Antonio De Magistris Elisa Cennamo Silvia Casalboni Francesca De Marco Roberta Rocchi Brice Ndogmo Beumo Valeria Cusani Mariarosa Gaudio Oliver Hartmann Andreas Bergman Maria Pia Ruggieri Salvatore Di Somma |
| author_facet | Ilaria Dafne Papasidero Gabriele Valli Dario Marin Alberto Del Sasso Antonio De Magistris Elisa Cennamo Silvia Casalboni Francesca De Marco Roberta Rocchi Brice Ndogmo Beumo Valeria Cusani Mariarosa Gaudio Oliver Hartmann Andreas Bergman Maria Pia Ruggieri Salvatore Di Somma |
| author_sort | Ilaria Dafne Papasidero |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: In order to accelerate the risk stratification of patients referred to the Emergency Department (ED) with interstitial pneumonia, it could be useful to provide new and effective laboratory tests for use. The aim of our study was to evaluate the prognostic role of two biomarkers, bio-adrenomedullin (Bio-ADM) and proenkephalin (penKid), in patients with interstitial pneumonia (IP) at ED admission. <i>Materials and Methods</i>: In 153 consecutive patients with IP, both from COVID-19 or non-COVID-19 etiology, we measured, in a prospective observational manner, penKid and Bio-ADM at ED admission and after 24 h. In order to evaluate patient outcomes, 30-day follow-ups were also performed. The endpoints were 24 h, 10-day, and 30-day mortality. <i>Results</i>: Both biomarkers were shown to be good predictors of adverse events at 30 days, with Bio-ADM outperforming penKid. Bio-ADM was linked with 24 h and 10-day patient mortality. Moreover, PenKid was related to parameters defining worsening kidney function. <i>Conclusions:</i> Both in patients with COVID-19 or non-COVID-19 interstitial pneumonia at ED admission, Bio-ADM and penKid were good predictors of patient mortality. To evaluate these two biomarkers could be considered to be useful during the first evaluation in the ED when integrated with clinical scores. |
| first_indexed | 2024-03-09T16:07:23Z |
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| id | doaj.art-5c65f907686148da8043928a097d0ad1 |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:07:23Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5c65f907686148da8043928a097d0ad12023-11-24T16:33:51ZengMDPI AGMedicina1010-660X1648-91442022-12-015812185210.3390/medicina58121852Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency DepartmentIlaria Dafne Papasidero0Gabriele Valli1Dario Marin2Alberto Del Sasso3Antonio De Magistris4Elisa Cennamo5Silvia Casalboni6Francesca De Marco7Roberta Rocchi8Brice Ndogmo Beumo9Valeria Cusani10Mariarosa Gaudio11Oliver Hartmann12Andreas Bergman13Maria Pia Ruggieri14Salvatore Di Somma15Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Emergency Medicine, San Giovanni Addolorata Hospital, 00184 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Emergency Medicine, San Giovanni Addolorata Hospital, 00184 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Clinical Pathology, San Giovanni Addolorata Hospital, 00184 Rome, ItalySphingoTec, 16761 Hennigsdorf, GermanySphingoTec, 16761 Hennigsdorf, GermanyDepartment of Emergency Medicine, San Giovanni Addolorata Hospital, 00184 Rome, ItalyPostgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy<i>Background and Objectives</i>: In order to accelerate the risk stratification of patients referred to the Emergency Department (ED) with interstitial pneumonia, it could be useful to provide new and effective laboratory tests for use. The aim of our study was to evaluate the prognostic role of two biomarkers, bio-adrenomedullin (Bio-ADM) and proenkephalin (penKid), in patients with interstitial pneumonia (IP) at ED admission. <i>Materials and Methods</i>: In 153 consecutive patients with IP, both from COVID-19 or non-COVID-19 etiology, we measured, in a prospective observational manner, penKid and Bio-ADM at ED admission and after 24 h. In order to evaluate patient outcomes, 30-day follow-ups were also performed. The endpoints were 24 h, 10-day, and 30-day mortality. <i>Results</i>: Both biomarkers were shown to be good predictors of adverse events at 30 days, with Bio-ADM outperforming penKid. Bio-ADM was linked with 24 h and 10-day patient mortality. Moreover, PenKid was related to parameters defining worsening kidney function. <i>Conclusions:</i> Both in patients with COVID-19 or non-COVID-19 interstitial pneumonia at ED admission, Bio-ADM and penKid were good predictors of patient mortality. To evaluate these two biomarkers could be considered to be useful during the first evaluation in the ED when integrated with clinical scores.https://www.mdpi.com/1648-9144/58/12/1852COVID-19interstitial pneumoniaBio-ADMpenKidacute kidney injury30-day mortality |
| spellingShingle | Ilaria Dafne Papasidero Gabriele Valli Dario Marin Alberto Del Sasso Antonio De Magistris Elisa Cennamo Silvia Casalboni Francesca De Marco Roberta Rocchi Brice Ndogmo Beumo Valeria Cusani Mariarosa Gaudio Oliver Hartmann Andreas Bergman Maria Pia Ruggieri Salvatore Di Somma Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department Medicina COVID-19 interstitial pneumonia Bio-ADM penKid acute kidney injury 30-day mortality |
| title | Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department |
| title_full | Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department |
| title_fullStr | Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department |
| title_full_unstemmed | Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department |
| title_short | Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department |
| title_sort | utility of measuring circulating bio adrenomedullin and proenkephalin for 30 day mortality risk prediction in patients with covid 19 and non covid 19 interstitial pneumonia in the emergency department |
| topic | COVID-19 interstitial pneumonia Bio-ADM penKid acute kidney injury 30-day mortality |
| url | https://www.mdpi.com/1648-9144/58/12/1852 |
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