Development of a Detection System for <i>ESR1</i> Mutations in Circulating Tumour DNA Using PNA-LNA-Mediated PCR Clamping

Development of a Detection System for <i>ESR1</i> Mutations in Circulating Tumour DNA Using PNA-LNA-Mediated PCR Clamping

Although circulating tumour DNA (ctDNA)-based next-generation sequencing (NGS) is a less invasive method for assessing <i>ESR1</i> mutations that are essential mechanisms of endocrine therapy resistance in patients with oestrogen receptor-positive breast cancer, adequate amounts of DNA a...

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Bibliographic Details
Main Authors: Yuki Kojima, Emi Noguchi, Tomomi Yoshino, Shigehiro Yagishita, Shu Yazaki, Hitomi S. Okuma, Tadaaki Nishikawa, Maki Tanioka, Kazuki Sudo, Tatsunori Shimoi, Ayaka Kazama, Hiroshi Terasaki, Sachiro Asano, Yasuhiro Fujiwara, Akinobu Hamada, Kenji Tamura, Kan Yonemori
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Diagnostics
Subjects:
<i>ESR1</i> mutations
breast cancer
peptide nucleic acid and locked nucleic acid polymerase chain reaction
next-generation sequencing
circulating tumour DNA
Online Access:https://www.mdpi.com/2075-4418/13/12/2040

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