Targeting SARS-CoV-2 Non-Structural Proteins
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/13002 |
| _version_ | 1797584397623361536 |
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| author | Donald Tam Ana C. Lorenzo-Leal Luis Ricardo Hernández Horacio Bach |
| author_facet | Donald Tam Ana C. Lorenzo-Leal Luis Ricardo Hernández Horacio Bach |
| author_sort | Donald Tam |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs. |
| first_indexed | 2024-03-10T23:51:24Z |
| format | Article |
| id | doaj.art-5c674ef7f35d426cabc07bf80697c8ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:51:24Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5c674ef7f35d426cabc07bf80697c8ff2023-11-19T01:33:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161300210.3390/ijms241613002Targeting SARS-CoV-2 Non-Structural ProteinsDonald Tam0Ana C. Lorenzo-Leal1Luis Ricardo Hernández2Horacio Bach3Division of Infectious Disease, Department of Medicine, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, CanadaDivision of Infectious Disease, Department of Medicine, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, CanadaLaboratorio de Investigación Fitoquímica, Departamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, Ex Hacienda Sta. Catarina Mártir S/N, San Andrés Cholula 72810, MexicoDivision of Infectious Disease, Department of Medicine, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, CanadaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.https://www.mdpi.com/1422-0067/24/16/13002SARS-CoV-2non-structural proteinvirulence factorsdrug targetingmulti-drug regimenreplication transcription complex |
| spellingShingle | Donald Tam Ana C. Lorenzo-Leal Luis Ricardo Hernández Horacio Bach Targeting SARS-CoV-2 Non-Structural Proteins International Journal of Molecular Sciences SARS-CoV-2 non-structural protein virulence factors drug targeting multi-drug regimen replication transcription complex |
| title | Targeting SARS-CoV-2 Non-Structural Proteins |
| title_full | Targeting SARS-CoV-2 Non-Structural Proteins |
| title_fullStr | Targeting SARS-CoV-2 Non-Structural Proteins |
| title_full_unstemmed | Targeting SARS-CoV-2 Non-Structural Proteins |
| title_short | Targeting SARS-CoV-2 Non-Structural Proteins |
| title_sort | targeting sars cov 2 non structural proteins |
| topic | SARS-CoV-2 non-structural protein virulence factors drug targeting multi-drug regimen replication transcription complex |
| url | https://www.mdpi.com/1422-0067/24/16/13002 |
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