New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes

New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes

Saccharomonospora sp. UR22 and Dietzia sp. UR66, two actinomycetes derived from the Red Sea sponge Callyspongia siphonella, were co-cultured and the induced metabolites were monitored by HPLC-DAD and TLC. Saccharomonosporine A (1), a novel brominated oxo-indole alkaloid, convolutamydine F (2) along...

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Bibliographic Details
Main Authors: Seham S. El-Hawary, Ahmed M. Sayed, Rabab Mohammed, Mohammad A. Khanfar, Mostafa E. Rateb, Tarek A. Mohammed, Dina Hajjar, Hossam M. Hassan, Tobias A. M. Gulder, Usama Ramadan Abdelmohsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Chemistry
Subjects:
Saccharomonospora sp.
Dietzia sp.
actinomycetes
Saccharomonosporine A
convolutamydine F
docking
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00538/full

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