Function of TRP channels in monocytes/macrophages
The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1187890/full |
| _version_ | 1827922416983080960 |
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| author | Jiangbo Wu Jiangbo Wu Zhuo Li Zhuo Li Ya Deng Ya Deng Xianmin Lu Xianmin Lu Chen Luo Chen Luo Xingyi Mu Xingyi Mu Ting Zhang Ting Zhang Qi Liu Qi Liu Siqi Tang Siqi Tang Jiajing Li Jiajing Li Qimin An Qimin An Dongdong Fan Dongdong Fan Yiwei Xiang Yiwei Xiang Xianli Wu Xianli Wu Yanxia Hu Yanxia Hu Qian Du Qian Du Jingyu Xu Rui Xie |
| author_facet | Jiangbo Wu Jiangbo Wu Zhuo Li Zhuo Li Ya Deng Ya Deng Xianmin Lu Xianmin Lu Chen Luo Chen Luo Xingyi Mu Xingyi Mu Ting Zhang Ting Zhang Qi Liu Qi Liu Siqi Tang Siqi Tang Jiajing Li Jiajing Li Qimin An Qimin An Dongdong Fan Dongdong Fan Yiwei Xiang Yiwei Xiang Xianli Wu Xianli Wu Yanxia Hu Yanxia Hu Qian Du Qian Du Jingyu Xu Rui Xie |
| author_sort | Jiangbo Wu |
| collection | DOAJ |
| description | The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are expressed in mammalian macrophages. TRP channels may be involved in various signaling pathways in the development of various systemic diseases through changes in intracellular concentrations of cations such as calcium and magnesium. These TRP channels may also intermingle with macrophage activation signals to jointly regulate the occurrence and development of diseases. Here, we summarize recent findings on the expression and function of TRP channels in macrophages and discuss their role as modulators of macrophage activation and function. As research on TRP channels in health and disease progresses, it is anticipated that positive or negative modulators of TRP channels for treating specific diseases may be promising therapeutic options for the prevention and/or treatment of disease. |
| first_indexed | 2024-03-13T04:42:20Z |
| format | Article |
| id | doaj.art-5c67aeffa8cb4bbb8884caa60e8b5d51 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T04:42:20Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5c67aeffa8cb4bbb8884caa60e8b5d512023-06-19T04:50:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11878901187890Function of TRP channels in monocytes/macrophagesJiangbo Wu0Jiangbo Wu1Zhuo Li2Zhuo Li3Ya Deng4Ya Deng5Xianmin Lu6Xianmin Lu7Chen Luo8Chen Luo9Xingyi Mu10Xingyi Mu11Ting Zhang12Ting Zhang13Qi Liu14Qi Liu15Siqi Tang16Siqi Tang17Jiajing Li18Jiajing Li19Qimin An20Qimin An21Dongdong Fan22Dongdong Fan23Yiwei Xiang24Yiwei Xiang25Xianli Wu26Xianli Wu27Yanxia Hu28Yanxia Hu29Qian Du30Qian Du31Jingyu Xu32Rui Xie33Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are expressed in mammalian macrophages. TRP channels may be involved in various signaling pathways in the development of various systemic diseases through changes in intracellular concentrations of cations such as calcium and magnesium. These TRP channels may also intermingle with macrophage activation signals to jointly regulate the occurrence and development of diseases. Here, we summarize recent findings on the expression and function of TRP channels in macrophages and discuss their role as modulators of macrophage activation and function. As research on TRP channels in health and disease progresses, it is anticipated that positive or negative modulators of TRP channels for treating specific diseases may be promising therapeutic options for the prevention and/or treatment of disease.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1187890/fullmonocytesmacrophageTRP channelsmacrophage polarizationsystem disease |
| spellingShingle | Jiangbo Wu Jiangbo Wu Zhuo Li Zhuo Li Ya Deng Ya Deng Xianmin Lu Xianmin Lu Chen Luo Chen Luo Xingyi Mu Xingyi Mu Ting Zhang Ting Zhang Qi Liu Qi Liu Siqi Tang Siqi Tang Jiajing Li Jiajing Li Qimin An Qimin An Dongdong Fan Dongdong Fan Yiwei Xiang Yiwei Xiang Xianli Wu Xianli Wu Yanxia Hu Yanxia Hu Qian Du Qian Du Jingyu Xu Rui Xie Function of TRP channels in monocytes/macrophages Frontiers in Immunology monocytes macrophage TRP channels macrophage polarization system disease |
| title | Function of TRP channels in monocytes/macrophages |
| title_full | Function of TRP channels in monocytes/macrophages |
| title_fullStr | Function of TRP channels in monocytes/macrophages |
| title_full_unstemmed | Function of TRP channels in monocytes/macrophages |
| title_short | Function of TRP channels in monocytes/macrophages |
| title_sort | function of trp channels in monocytes macrophages |
| topic | monocytes macrophage TRP channels macrophage polarization system disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1187890/full |
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