ESTUDOS EM ANDAMENTO FASE IB E IIA: CROSSWALK-A E CROSSWALK-C, RANDOMIZADOS E CONTROLADOS POR PLACEBO - CROVALIMABE NO TRATAMENTO E PREVENÇÃO DE EPISÓDIOS VASO-OCLUSIVOS NA DOENÇA FALCIFORME
Introdução: Na doença falciforme (DF), uma mutação pontual no gene da beta-globina resulta na produção de hemoglobina S (HbS), que pode polimerizar-se após desoxigenação. A polimerização distorce a membrana dos glóbulos vermelhos e gera eritrócitos falciformes, contribuindo para oclusões microvascul...
Main Authors: | MA Salvino, B Antmen, FC Asirwa, S Chonat, L Franceschi, P Eleftheriou, A Inati, J Mahlangu, E Nur, S Payá-Pernía, A Charania, D Gradinaru, A Hsia, T Perretti, S Sreckovic, P Bartolucci |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-10-01
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Series: | Hematology, Transfusion and Cell Therapy |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923003887 |
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