Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis
Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/ste...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1050954/full |
| _version_ | 1828034722203172864 |
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| author | Jun Liu Lili Yang Kexin Liu Feng Gao |
| author_facet | Jun Liu Lili Yang Kexin Liu Feng Gao |
| author_sort | Jun Liu |
| collection | DOAJ |
| description | Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction via discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering. |
| first_indexed | 2024-04-10T15:36:34Z |
| format | Article |
| id | doaj.art-5c6a1baedcce490f872888b72df13ed1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T15:36:34Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5c6a1baedcce490f872888b72df13ed12023-02-13T04:37:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-02-011410.3389/fphar.2023.10509541050954Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesisJun Liu0Lili Yang1Kexin Liu2Feng Gao3Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Spinal Surgery, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, ChinaBone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction via discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering.https://www.frontiersin.org/articles/10.3389/fphar.2023.1050954/fullbone tissue engineeringscaffoldbiomaterialhydrogelangiogenesis |
| spellingShingle | Jun Liu Lili Yang Kexin Liu Feng Gao Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis Frontiers in Pharmacology bone tissue engineering scaffold biomaterial hydrogel angiogenesis |
| title | Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis |
| title_full | Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis |
| title_fullStr | Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis |
| title_full_unstemmed | Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis |
| title_short | Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis |
| title_sort | hydrogel scaffolds in bone regeneration their promising roles in angiogenesis |
| topic | bone tissue engineering scaffold biomaterial hydrogel angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1050954/full |
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